C2 Chronic Inflammation Flashcards
characterized by an elevation of body temperature, usually by 1° to 4°C, is one of the most prominent manifestations of the acute-phase response, especially when inflammation is associated with infection
Fever
Special type of chronic inflammation and this
mechanism for dealing indigestible substances
Granulomatous inflammation
is a common feature of inflammatory reactions, especially those induced by bacterial infections.
Leukocytosis
inflammation of prolonged duration (weeks or months) in which infl ammation, tissue injury, and attempts at repair coexist, in varying combinations
Chronic Inflammation
dominant cellular player in chronic inflammation
Macrophage
Arachidonic Acid-derived mediators
eicosanoids
Excess body fluid in the cavities of the body
Effusion
Marked by an outpouring of thin fluid from the blood
serum or secretions of mesothelial cells lining the
body cavities (an effusion)
SEROUS INFLAMMATION
proteins found in plasma and the activation of this complement system lead to the formation of your membrane
attack complex; The membrane attack complex cause cell lysis to your target cells
Complement system
when the nuclei are
arranged around the periphery of the cell in a horseshoe pattern.
Langhans giant cells
The recruitment of these cells to the area ofinjury
Chemotaxis
Characterized by the production of large amount of
pus (“nana”) consisting of neutrophils, necrotic cells,
and edema fluid
SUPPURATIVE INFLAMMATION
plasma proteins, mostly synthesized in the liver, whose plasma concentrations may increase several hundred-fold as part of the response to inflammatory stimuli
Acute-phase proteins
a focus of chronic inflammation consisting of
a microscopic aggregation of macrophages that are transformed into epithelium-like cells, surrounded by a collar of mononuclear
leukocytes, principally lymphocytes and occasionally plasma cells
Granuloma
found in Mast cells, basophils; POWERFUL vasodilator; Vasoactive “amine”; IgE on mast cell
Histamine
secreted by sensory nerves and various leukocytes, and play a role in the initiation and propagation of an inflammatory response
Neuropeptides
When a foreign pathogenic agent or other
indigestible material is identifies within the
cytoplasm of multinucleated giant cell
Foreign body giant cells
Characteristic inflammation of body cavities; develop when the vascular leaksare large enough or there is a procoagulant stimulus in the interstitium
FIBROUS INFLAMMATION
These are very very destructive such as O2 – (superoxide); H2O2 (peroxide)l OH-
(hydroxyl radical)
Free Radicals
is a distinctive pattern of chronic inflammation that is encountered in a limited number of infectious and some noninfectious conditions
Granulomatous infl ammation
also called azurophilic or nonspecific and contain lysozyme, collagenase, gelatinase, lactoferrin, plasminogen activator,
histaminase, and alkaline phosphatase
Primary granules
Primarily serves to contain and remove a pathological agent or process within a tissue
CHRONIC INFLAMMATION
This type of immune response produces granulomas usually when the inciting agent is poorly degradable or
particulate
Immune granulomas
