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BZD Flashcards

1
Q

Short acting bzd for favorable asa hypnotic than sedative drug

A

Triazolam

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2
Q

Use for anxiety and more toxic in overdose than other bzd

A

Alprazolam

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3
Q

Drugs for epilepticus

A

Lorazepam
Diazepam

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4
Q

Bzd drug for seizures

A

Clonazepam

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5
Q

⚬ muscular disorders,old first-line tmt for status epilepticus

A

Diazepam

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6
Q

Aka nordiazepam

A

Desmethydiazepam

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7
Q

• ↓REM sleep

A

Zolpidem

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8
Q

Newer gen of sedative and hypnotic drug with a Short half life and ↓latency of sleep onset

A

Zaleplon

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9
Q

a hypnotic drug which ↑sleep time, stage 2 NREM sleep

A

ESZOPICLONE

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10
Q

non-24hour sleep-wake disorder

A

Tasimelteon

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11
Q

Concurrent use with fluvoxamine increases the peak plasma conc of ramelteon over 50-fold

A

RAMELTEON

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12
Q

relieves anxiety without causing marked sedative, hypnotic, or euphoric effects

A

BUSPIRONE

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13
Q

Medical term of pins and needes

A

Paresthesias

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14
Q

Bzd drug for amnesia with a duration of action of 3-8hrs

A

Midazolam

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15
Q

Intermediate acting Bzd drug for insomia

A

Temazepam

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16
Q

Long acting bzd which administered indecreasing doses to px with withdrawal

A

Chlordiazepoxide

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17
Q

Date rape drug

A

Flunitrazepam

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18
Q

Knock out drops

A

Mickey finn

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19
Q

active metabolite of chlordiazepoxide, diazepam, prazepam, and clorazepate

A

Desmethyldiazepam

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20
Q

structurally unrelated to benzodiazepines, share a similar mechanism of action

A

ZOLPIDEM

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21
Q

slow-onset anxiolytic agent

A

BUSPIRONE

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22
Q

may take 3-4weeks to develop anxiolytic effects
Not for acute anxiety

A

BUSPIRONE

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23
Q

2 bzd blokers

A

Flumazenil,
B-carbolines

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24
Q

Has a a/e of paradoxical reactions

A

Bzd blokers ( flumazenil, B-carbolines)

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25
Q

In the tmt of GAD and phobias

A

Bzd

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26
Q

increase in the frequency of channel-opening events

A

Benzodiazepines

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27
Q

do not substitute for GABA but appear to enhance GABA’s effects allosterically without directly activating GABA-A receptors

A

Benzodiazepines

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28
Q

negative allosteric modulators of GABA-receptor function

A

INVERSE AGONISTS

29
Q

OREXIN RECEPTOR ANTAGONISTS FDA-approved:

A

Suvorexant

30
Q

line tmt for febrile seizure

A

Phenobarbital

31
Q

INTERMEDIATE-ACTING

A

• Amobarbital • Butabarbital

32
Q

Barbiturates for anesthetic

A

Thiopental

33
Q

increase the duration of the GABA-gated chloride channel openings

A

Barbiturates

34
Q

AMPA

A

α-amino-3-hydroxy-5- methylisoxazole-4- propionic acid

35
Q

ULTRA SHORT-ACTING

A

• Thiopental
• Thioamylal
• Methohexital

36
Q

LONG-ACTING DOA

37
Q

As a component if balanced anesthesia (IV)

A

Thiopental

38
Q

For sedation and amnesia before and during medical and surgical procedures

A

Thiopental
Midazolam
Triazolam

39
Q

For sedation and amnesia before and during medical and surgical procedures

A

Thiopental
Triazoalam
Midazolam

40
Q

INTERMEDIATE-ACTING barbiturates

A

• Amobarbital • Butabarbital

41
Q

tonic-clonic seizure

A

• Phenobarbital

42
Q

OREXIN RECEPTOR ANTAGONISTS Use for mgt insomia and slepig disorders

A

Almorexant & Suvorexant

43
Q

Notable barbiturates available in the market

A

Phenobarbital

44
Q

also depress the actions of glutamic acid via binding to the AMPA receptor

A

Barbiturates

45
Q

Previously known as grand mal seizure

A

tonic-clonic seizure

46
Q

T/F drugs must either be highly hydrophobic or engage specific transport mechanisms

47
Q

respond to changes in the membrane potential of the cell

A

VOLTAGE-GATED CHANNELS

48
Q

responsible for fast synaptic transmission typical of hierarchical pathways in the CNS (ms)

A

LIGAND-GATED CHANNELS

49
Q

reduce the amount of transmitter released from the terminals of sensory fibers

A

Axoaxonic synapses

50
Q

causes the release of the peptide substance P from sensory neurons

A

Reserpine
Capsaicin

51
Q

retrograde signaling

A

Endocannabinoids

52
Q

seven-transmembrane G protein-coupled receptors

A

METABOTROPIC RECEPTORS

53
Q

highly concentrated on the initial segment of the axon, which initiates the all-or-nothing fast action potential

A

VOLTAGE-GATED CHANNELS

54
Q

cAMP, block metabolism, prolong action

A

methylxanthines

55
Q

blocks NMDA subtype of glutamate receptors = anesthesia

56
Q

all the pathways directly involved in sensory perception and motor control

A

HIERARCHICAL SYSTEMS

57
Q

blocks glycine = convulsant action

A

strychnine

58
Q

form the interconnecting pathways that transmit signals over long distances

A

projection neurons

59
Q

axons arborize in the immediate vicinity of the cell body

A

local circuit neurons

60
Q

neurotransmitters are produced by only a limited number of neurons whose cell bodies are located in small discrete nuclei, often in the brainstem

A

NONSPECIFIC OR DIFFUSE NEURONAL SYSTEMS

61
Q

GLUTAMATE receptors

A

AMPA
kainic acid
N-methyl-D-aspartate

62
Q

GABA & Glycine receptors

A

GABA -A and GABA-B

63
Q

first compound to be identified pharmacologically as a transmitter in the CNS

A

ACETYLCHOLINE

64
Q

no orexin

A

narcolepsy

65
Q

may affect memory, cognition, and pain perception by this mechanism

A

Endocannabinoids

66
Q

hypothesized to be a retrograde messenger

A

Nitric oxide

67
Q

inhibit release of both amino acid and monoamine transmitters

68
Q

established for vascular smooth muscle

A

Nitric oxide

PCOL (4 decks)

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