Buzz Words Increased Risk of Cancer

Question 1

Ataxia-telangiectasia

Answer 1

Lymphoreticular malignancy and ataxia, recurrent infections

Question 2

Gorlin syndrome

Answer 2

Medulloblastoma, fibrosarcomas, ovarian fibromas

Question 3

Bloom syndrome

Answer 3

Leukemia or GI, photodistributed rash

Question 4

Birt-Hogg-Dube syndrome

Answer 4

renal, thyroid (medullary), colon cancer, and fibrofolliculomas

Question 5

Howel-Evans syndrome

Answer 5

esophageal cancer, focal pressure PPK

Question 6

Cowden syndrome

Answer 6

thyroid (follicular), breast, colon cancer, trichilemmomas

Question 7

Maffucci syndrome

Answer 7

chondrosarcoma, endochondromas, venous malformations

Question 8

Gardner syndrome

Answer 8

colon cancer, odontogenic cysts

Question 9

X-linked ichthyosis

Answer 9

testicular cancer, cryptorchidism

Question 10

Muir-Torre syndrome

Answer 10

sebaceous cancer, sebaceous adenomas

Question 11

MEN 2b

Answer 11

thyroid (medullary) cancer, mucosal neuromas

Question 12

Leiomyomatosis

Answer 12

renal cell carcinoma, uterine/cutaneous leiomyomas

Question 13

Dermatomyositis

Answer 13

ovarian, lung, colorectal, pancreatitc, poikiloderma

Question 14

Sweet’s syndrome, pyoderma gangrenosum (atypical bullous form)

Answer 14

AML, neutrophilic dermatosis

Question 15

Dermatitis herpetiformis

Answer 15

GI lymphoma, pruritic vesicles (extensor surfaces)

Question 16

NF1

Answer 16

juvenile myelomonocytic leukemia, JXG

Question 17

Multicentric reticulohistiocytosis

Answer 17

various cancers (30% of cases), destructive arthritis

Question 18

Tuberous sclerosis

Answer 18

renal cell carcinoma (rare), shagreen patches

Question 19

Dyskeratosis congenita

Answer 19

SCC, leukoplakia, nail dystrophy, bone marrow failure

Question 20

Rothmunc-Thomson syndrome

Answer 20

osteosarcoma, hypoplastic thumbs, photosensitivity

Question 21

Necrolytic migratory erythema

Answer 21

glucagonoma (pancreatic tumor), erythematous plaques (thighs/groin/perineum)