Bunyavirus Flashcards
Which viruses can undergo reassortment of RNA segments?
Bunyaviridae
From where does the Bunyavirus get its envelope?
Budding through the Golgi Apparatus
How many serogroups of Bunyavirus are there?
10
Which bunyavirus causes encephalitis?
California Encephalitis Virus
What is the clinical presentation of California Encephalitis Virus?
- Abrupt Onset
- Bifrontal Headache
- Fever, vomiting
- Aseptic Meningitis
What is LaCrosse Encephalitis?
A type of California Encephalitis Virus
What are the types of Bunyavirus that can cause hemorrhagic fever?
- Orthobunyavirus (Bunyawera Serogroup)
- Phlebovirus
- Hantavirus
- Arenaviridae
How is Orthobunyavirus transmitted?
Ticks
Which viruses cause Crimean Congo Hemorrhagic Fever?
Orthobunyavirus (Bunyawera Serogroup)
How is Phlebovirus transmitted?
Sand flies
What are the clinical symptoms of Phlebovirus?
HA, Fever, myalgia, photophobia, stiff neck, papules (recovery in 2yrs)
Which virus infects sheep and may be transmitted to humans?
Rift Valley Fever Virus
What are the symptoms of Ridt Valley Fever Virus?
Saddleback fever, GI sx, Joint pain, hemorrhagic fever
What are the two types of Hantavirus?
- Korean Hemorrhagic Fever Virus
2. Hantavirus Pulmonary Syndrome
Which disorder causes renal failure and may be transmitted by urine/feces of rodents?
Korean Hemorrhagic Fever Virus
What is the cause of Hantavirus Pulmonary Syndrome?
Aerosols that originate from mouse feces that are burned by Native Americans of the Southwest
What is an effective treatment for Hantavirus Pulmonary Syndrome?
- Ribavirin
What are the two groups of Arenavirus?
- Old World (Lymphocytic Choriomeningitis Virus (LCM) and Lassa Virus)
- New World (Tacaribe Virus, Junin and Machupo)
Which demographic is susceptible to LCM Virus?
Lab workers in close contact with rodents and hamster owners
What is the clinical presentation of Lymphocytic Choriomeningitis Virus (LCM)?
Mild Influenze like symptoms, possible aseptic meningitis
Which virus can cause serious fetal disease in pregnant women?
LCM
Which virus results in a severe febrile illness involving many organs that causes skin hemorrhages, mouth ulcers and muscle ache?
Lassa Virus
Where is Lassa Virus usually seen?
Africa
Where is Tacaribe Complex usually seen?
South America
What is a hemorrhagic fever?
Petechiae, bleeding in GI, uterus, nasal and GU tract with a fever
