Bullous disease Flashcards
Where do blisters form in bullus pemphigoid?
sub-epidermal
Where do blisters form in bullus pemhigus?
intra-epidermal
What is seen clinically in an intraepidermal blistering condition?
erosions
What is the most common autoimmune blistering disease?
bullous pemphigoid
How does bullous pemphigoid present?
large localised bullae
Who is affected by bullous pemphigoid?
> 60 yrs old
What is the pathology of bullus pemphigoid?
IgG autoantibodies formed against basement membrane
How is bullous pemphigoid treated?
if localised high potency topical steroids
if generalised prednisolone 40-80mg/day for 2 weeks
What is the prognosis of bullous pemphigoid?
benign, self-limiting with no relapse
most remission 3-6 months
How does pemphigus present?
flaccid erosions on skin and mucosal membranes esp mouth
What is Nikolsky sign?
rubbing sideways on skin will induce a blister in pemphigus
What is seen on histology of pemphigus?
intra-epidermal split
What is the pathology of pemphigus?
IgG autoantibodies against desmosomes
How is pemphigus treated?
high dose intermediate cyclophosphamide + high dose steroids (dexamethasone)
What is the prognosis for pemphigus?
10-20% mortality
