Bugs

Question 1

protein A

Answer 1

surface protein on Staph that binds Fc of IgG, interferes with opsonization

Question 2

TSST-1

Answer 2

Staph toxin causing toxic shock syndrome, superantigen

Question 3

staph enderotoxin

Answer 3

causes food poisosing from preformed staph toxin, from improperly stored food, 4 hours after eating

Question 4

exfoliative toxin

Answer 4

in staph, causes blisters

Question 5

SSp-1 and SSP2

Answer 5

fimbriae (pili) on staph epidermidis

Question 6

AtlE

Answer 6

surface peptidoglycan hydrolase that binds to polystyrene, staph epi

Question 7

treatment for staph epi

Answer 7

vancomycin, linezolid and daptomycin

Question 8

types of issues in Strep A infections

Answer 8

1. Skin and mucous membrane infections (impetigo)
2. deep tissue infetions (nec fas, cellulitis)
3. toxigenic (scarlet fever, toxic shock)
4. PSGN
5. rheumatic fever

Question 9

M protein

Answer 9

major virulence factor in Group A strep, attachment, resistant to phagocytosis and complement

Question 10

exotoxins in necrotizing fasciitis

Answer 10

streptolysins, stroptokinase, DNAse B

Question 11

treatment for GAS

Answer 11

clindamycin and penicillin

Question 12

strep bovis

Answer 12

50% colon cancer when in blood stream, can cause endocarditis

Question 13

clinical presentation in strep pneumoniae

Answer 13

Meningitis
Otitis media
Pnemonia
Sinusitis

Question 14

virulence factor in penumococcus

Answer 14

1. IgA protease
2. phosphoryl choline
3. pneumolysin -
4. polysaccharide capsule

Question 15

pneumolysin

Answer 15

pore forming toxin of pneumococcus that impairs mucociliary clearance and kills neutrophils

Question 16

drugs used to treat pseudomonas

Answer 16

beta-lactams (piperacillin and ticarcillin) fluoroqunolones and aminoglycosides

Question 17

currant jelly sputum

Answer 17

klebsiela

Question 18

two aerobic gram negatives talked about in class

Answer 18

pseudomonas and klebsiella

Question 19

bug that is in abcesses from class

Answer 19

bacteroides

Question 20

difference between babies and adults in C botulinum

Answer 20

adult - toxins

babies - spores

Question 21

two results of C perfringens

Answer 21

1. gas ganagrene - cellulitis, myonecrosis

2. food poisioning - toxin or bacteria

Question 22

alpha toxin - lectithinase

Answer 22

in C perfringens - damages membranes and is hemolytic

Question 23

acid labile diarehha bug

Answer 23

v. cholera

Question 24

examples of secretory diarrhea

Answer 24

cholera, ETEC, b cereus and s aureus

Question 25

facts about v cholerae

Answer 25

gram negative curved bacillus, acid labilie, produces mucus, uses TCP pillae, does not penetrate gut, rice water diarrhea in small colon

Question 26

facts about ETEC

Answer 26

like cholera, two toxins, uses fimbrie, in small bowel

Question 27

why E coli can become a pathogen

Answer 27

1. virulence factors - toxins, adherence, entry | 2. extraintestinal colonization - pili and polysaccharide capsule

Question 28

e coli K1

Answer 28

polysaccharide capsule seen in meningitis

Question 29

two toxins in ETEC

Answer 29

heat labile - increase cAMP heat stabe - increase cGMP EL agua de san gabriel

Question 30

guaiac test

Answer 30

for hemoglobin in stool

Question 31

facts of non-typhoid salmonella

Answer 31

undercoked chicken, small intestine, entry into cells, extracellular and within, damage can lead to Cl- secretion - usually in immmunocompromised *type 3 secretion

Question 32

splash and membrane rupture

Answer 32

salmonella

Question 33

guillain barre and reactive arthiritis

Answer 33

campylobacter

Question 34

facts of salmonella typhi

Answer 34

human to human, in gall bladder, fever, not always diarrhea, can spread systemically

Question 35

dysentery

Answer 35

shigella

Question 36

facts of shigella

Answer 36

acid resistant, invades M cellls, disrupts tight junctions, localized to GI, comet tail, type 3 secretion, shiga toxin inhibits pretein synthesis

Question 37

sorbitol negative

Answer 37

EHEC

Question 38

what is NOT treated with antibiotics

Answer 38

EHEC

Question 39

bacteria that can grow in neutrophils

Answer 39

anaplasma

Question 40

epithelial cell bugs

Answer 40

shigella, salmonella, chlamydia, listeria

Question 41

listeria facts

Answer 41

pregnant women, intracellular pathogens, milk and cheeses, actin rockets, receptor driven uptake

Question 42

internalins

Answer 42

on listeria for growth factor receptor or cell adhesion receptor

Question 43

bugs that use type 3 secretion system to get in

Answer 43

salmonella, shigella

Question 44

bug that hijacks material from endosomes

Answer 44

salmonella

Question 45

bug that hijacks from trans golgi and ER

Answer 45

chlymidia