Bugs Flashcards

1
Q

protein A

A

surface protein on Staph that binds Fc of IgG, interferes with opsonization

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2
Q

TSST-1

A

Staph toxin causing toxic shock syndrome, superantigen

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3
Q

staph enderotoxin

A

causes food poisosing from preformed staph toxin, from improperly stored food, 4 hours after eating

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4
Q

exfoliative toxin

A

in staph, causes blisters

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5
Q

SSp-1 and SSP2

A

fimbriae (pili) on staph epidermidis

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6
Q

AtlE

A

surface peptidoglycan hydrolase that binds to polystyrene, staph epi

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7
Q

treatment for staph epi

A

vancomycin, linezolid and daptomycin

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8
Q

types of issues in Strep A infections

A
  1. Skin and mucous membrane infections (impetigo)
  2. deep tissue infetions (nec fas, cellulitis)
  3. toxigenic (scarlet fever, toxic shock)
  4. PSGN
  5. rheumatic fever
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9
Q

M protein

A

major virulence factor in Group A strep, attachment, resistant to phagocytosis and complement

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10
Q

exotoxins in necrotizing fasciitis

A

streptolysins, stroptokinase, DNAse B

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11
Q

treatment for GAS

A

clindamycin and penicillin

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12
Q

strep bovis

A

50% colon cancer when in blood stream, can cause endocarditis

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13
Q

clinical presentation in strep pneumoniae

A

Meningitis
Otitis media
Pnemonia
Sinusitis

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14
Q

virulence factor in penumococcus

A
  1. IgA protease
  2. phosphoryl choline
  3. pneumolysin -
  4. polysaccharide capsule
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15
Q

pneumolysin

A

pore forming toxin of pneumococcus that impairs mucociliary clearance and kills neutrophils

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16
Q

drugs used to treat pseudomonas

A

beta-lactams (piperacillin and ticarcillin) fluoroqunolones and aminoglycosides

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17
Q

currant jelly sputum

A

klebsiela

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18
Q

two aerobic gram negatives talked about in class

A

pseudomonas and klebsiella

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19
Q

bug that is in abcesses from class

A

bacteroides

20
Q

difference between babies and adults in C botulinum

A

adult - toxins

babies - spores

21
Q

two results of C perfringens

A
  1. gas ganagrene - cellulitis, myonecrosis

2. food poisioning - toxin or bacteria

22
Q

alpha toxin - lectithinase

A

in C perfringens - damages membranes and is hemolytic

23
Q

acid labile diarehha bug

A

v. cholera

24
Q

examples of secretory diarrhea

A

cholera, ETEC, b cereus and s aureus

25
Q

facts about v cholerae

A

gram negative curved bacillus, acid labilie, produces mucus, uses TCP pillae, does not penetrate gut, rice water diarrhea in small colon

26
Q

facts about ETEC

A

like cholera, two toxins, uses fimbrie, in small bowel

27
Q

why E coli can become a pathogen

A
  1. virulence factors - toxins, adherence, entry

2. extraintestinal colonization - pili and polysaccharide capsule

28
Q

e coli K1

A

polysaccharide capsule seen in meningitis

29
Q

two toxins in ETEC

A

heat labile - increase cAMP
heat stabe - increase cGMP

EL agua de san gabriel

30
Q

guaiac test

A

for hemoglobin in stool

31
Q

facts of non-typhoid salmonella

A

undercoked chicken, small intestine, entry into cells, extracellular and within, damage can lead to Cl- secretion - usually in immmunocompromised

*type 3 secretion

32
Q

splash and membrane rupture

A

salmonella

33
Q

guillain barre and reactive arthiritis

A

campylobacter

34
Q

facts of salmonella typhi

A

human to human, in gall bladder, fever, not always diarrhea, can spread systemically

35
Q

dysentery

A

shigella

36
Q

facts of shigella

A

acid resistant, invades M cellls, disrupts tight junctions, localized to GI, comet tail, type 3 secretion, shiga toxin inhibits pretein synthesis

37
Q

sorbitol negative

A

EHEC

38
Q

what is NOT treated with antibiotics

A

EHEC

39
Q

bacteria that can grow in neutrophils

A

anaplasma

40
Q

epithelial cell bugs

A

shigella, salmonella, chlamydia, listeria

41
Q

listeria facts

A

pregnant women, intracellular pathogens, milk and cheeses, actin rockets, receptor driven uptake

42
Q

internalins

A

on listeria for growth factor receptor or cell adhesion receptor

43
Q

bugs that use type 3 secretion system to get in

A

salmonella, shigella

44
Q

bug that hijacks material from endosomes

A

salmonella

45
Q

bug that hijacks from trans golgi and ER

A

chlymidia