Brucella Flashcards
What are the 4 important Brucella species?
B. melitensis
B. abortus
B. suis
B. canis
What is the principle cause of human brucellosis?
B. melitensis
What is the pathogenesis of B. abortus?
No symptoms Spreads intracellular 1-6 weeks incubation period Regional lymphonodus Target organs
What is the pathogenesis of B. abortus in the uterus?
Placentoma and multiplication -> excretion and spread to bovines and humans
What is the pathogenesis of B. abortus in the fetus?
Fetus and multiplication
Abortion
Premature birth
Normal partus but calf is carrier
What is the pathogenesis of B. abortus in the udder?
Subclinical mastitis
Excretion and spread
How does B. abortus affect immunity?
When cellular immunity is not capable of killing all intracellular bacteria
How would B. abortus be Dx?
SAW or SAT Rose bengal test simple CFT ELISA IFN-gamma Skin test Bacteriology
What are the 3 types of test done for Brucellosis?
Brucellergen (skin) test
EU regulation
IFN-gamma test
What is tested for first to make sure you are dealing with Brucella?
IFN-gamma
T/F: Brucella suis is still present in wildlife
True
What are the 2 biovars pathogenic in pigs?
Biovar 1: reservoir in hares
Biovar 2: reservoir in hares
Biovar 3: reservoir in pigs
What are the CS of B. suis?
Abortion Orchitis Infertility Athritis Tendovaginitis Bursitis Osteomyelitis
What is the pathogenesis of B. suis?
Skin/mucosa -> regional lymph nodes -> bacteremia -> localization and abscess formation
How is Brucellosis Dx in wild boar?
Yersinia enterocolitica O9
Serological tests