BRTP09 Aerosol Medication Administration Flashcards

1
Q

Aerosol

A

A suspension of solid or liquid particles in a gas

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2
Q

Stability

A

The ability of an awrsol to remin in suspension over time

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3
Q

Instability

A

The tendency for particles to be removed from suspension

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4
Q

Ideal state

A

Particles that range from 0.01-3.0 microns in diameter

100-1000 particles per ml of gas

SIZE THAT PENETRATES ALVEOLI IN THE LUNGS

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5
Q

Penetration

A

Refers to the MAXIMUM DEPTH that suspended particles can be carried into the pulmonary tree by inahled tidal air

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6
Q

Deposition

A

Result of an aerosols eventual instabiltiy; particles “fall out” on a newrby surface

“Where it ends up landing”

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7
Q

Retention

A

Proportion of particles deposited within the respiratory tract

“How much enters the lungs and stay in the lungs”

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8
Q

Clearance

A

Removal, the fact that some particles are exhaled

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9
Q

Coalescence

A

Two particles form one larger particle

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10
Q

Nebulizer

A

A device that generates aerosol of uniform size

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11
Q

particle deposition

A

5-50 microns— get trapped in nose and upper airways

2 to 5 micron—— lower airways: bronchi

0.5 to 3 microns —– Parenchyma: alveolar region

(Anything less than 3 is acceptable)

The main goal with administering medicine is to reach the alveolar level

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12
Q

5 Factors that affect deposition (where it lands) and penetration (how far can it go)

A
  1. Gravity
  2. Kinetic Activity
  3. Particle Inertia
  4. Physical nature of aerosol
  5. Ventilatory pattern
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13
Q

Goal of aerosol therapy

A

Deliver directly to the site of action

Therapeutic action with selected agent (medication) with minimal systematic side effects (WHOLE BODY SIDE EFFECTS)]

Greater efficacy and safety

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14
Q

Hazards of aerosol therapy (Adverse drug reaction)

A
Cardiovascular effects (tachycardia and arrhythmias)
Muscle tremors
nervousness
headache 
insomnia

We stop treatment when HR increases by 20 bpm or a 20% increase in HR

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15
Q

More hazards of aerosol therapy

A
infection (not due to drug rather due to poor cleaning of equipment)
airway reactivity (bronchospasm)
pulmonary and systemic effects
drug concentration
eye irritation
secondhand exposure
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16
Q

Patient assessment includes

A
Vital signs: HR, RR, BP
breath pattern
breath sounds
pulse oximetry
peak flow rates (PEFR)
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17
Q

Peak flow meter

A

A small, handheld device used to monitor a person’s ability to breath out air.

When to use it?

assessing effectiveness of treatment
before taking meds and after

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18
Q

Optimal use of Peak flow meter

A
Move marker to bottom of scale
stand up straight
ensure tight seal
deep breath in
blow hard and fast
Repeat 3 times taking the best of three
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19
Q

MDI

A

metered-dose inhaler

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20
Q

DPI

A

Dry powder inhaler

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21
Q

Nebulizers

A

SVN (small volume)

LVN (large volume)

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22
Q

Hand bulb atomizer or spray pump

A

spray pump used for aerosol delivery to the UPPER RESPIRATORY Tract
Uses simple jet to produce large particles
Example: Nose sprayers to treat symptoms of allergic rhinitis and upper airway inflammation

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23
Q

3 types of MDI (metered-dose inhaler)

A
  1. conventional
  2. air actuated
  3. soft-mist
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24
Q

Advantages of a metered dose inhaler

A
Portable, compact
multidose convenience
short treatment time
reproducible emitted dose (which means it give a MEASURED dose of meds)
No drug preparation required
difficult to contaminant
25
Disadvantages of a metered dose inhaler
Hand-breath coordination required patient has to activate and properly inhale fixed drug dosage and doses often gets caught in oropharyngeal deposition difficulty determining remaining dose if theres no counter
26
Factors affecting the MDI performance and drug delivery
``` Must shake canister Storage temp nozzle size and cleanliness timing of actuation priming ( wasting a puff) characteristics of the patient overall technique ```
27
Optimal technique for MDI
warm and shake canister in hand assemble and uncap mouthpiece sit up straight (45-90 degrees) or stand breathe out normally open mouth technique: keep mouth open and tongue down closed mouth technique: place mouthpiece between lips with tongue out of the path
28
Optimal use continued for MDI
slowly breathe in as you activate the MDI Continue inspiration to total lung capacity (TLC) Hold breathe for 10 seconds wait 1 minute between puffs **IF TAKING STEROID PATIENT MUST RINSE MOUTH AFTER** ***RINSING MOUTH AFTER STERIOD PREVENTS ORAL THRUSH***
29
During treatment or inbetween meds the RT should
monitor patients vitals observe improvements or adverse reactions Troubleshoot absent or low aerosol output
30
Qday
once a day
31
BID
twice a day
32
TID
three times a day
33
QID
four times a day
34
Q4
every 4 hours
35
Advantages to using accessory devices with a MDI
reduce oropharyngeal drug impaction INCREASED DRUG ALMOST 4 TIMES MORE THAN JUST MDI ALONE no drug prep needed simplifies coordination and inhalation
36
Disadvantages of accessory devices for mdi
Larger more expensive and bulky some assembly may be required patient errors (firing multiple puffs into chamber could be a source of contamination if not cleaned well
37
2 types of MDI accessory devices
Valved holding chamber | Spacer
38
Valved holding chamber
Incorporates one or more low resistance valves to prevent aerosol in the chamber from clearing on exhalation reduces oral deposition and increases pulmonary deposition better for coordination issues than spacer feedback if inspiratory flow too fast (device will whistle or make "musical sound")
39
Spacer
simple VALVELESS extension device that adds distance between patients mouth and MDI outlet distance allows for reduction in particle size and decreases oral deposition helps with patient coordination of inhalation and actuation
40
DPI aka dry powdered inhalers
BREATH ACTUATED dosing system. The patient creates aerosol by generating inspiratory flow and volume
41
Major disadvantage to DPI
Adequate inspiratory flow is required for medication to be delivered Can result in high pharyngeal deposition Humidity can cause powder to clump and reduce fine particle mass **PATIENT HAS TO BE ABLE TO HAVE INSPIRATORY FLOW FROM 40-60**
42
Jet nebulizers
gas powered directed through a restricted orifice (the jet) Incorporates baffles to decrease the number of large aerosol particles Can be small volume neb or large volume neb due to reservoir size sidestream or mainstream
43
If you had to choose between a spacer and holding chamber which should you choose?
Valved holding chamber
44
Factors that affect performance of jet nebulizer
``` Gas flow and pressure humidity and temp drug formulation gas density nebulizer design- baffle and residual drug volume breathing pattern ```
45
advantages of Small volume nebulizer (SVN)
aerosolize several drugs can mix drugs if compatible minimal cooperation and coordination required works in several patients (age, distressed, debilitated) drug dose can be modified normal breathing pattern can be used
46
Small volume nebulizer disadvantages
Total treatment time can be 5-30 mins equipment required power source required if using a mask, drug delivery to the eyes is possibility variability of performance can be brand dependent
47
important facts about small volume nebulizers
USUALLY RUNS ON FLOW OF 6-8 LPM Can be driven on oxygen or air generally hold 2-6 ml of solution SHOULD BE USED INSTEAD OF MDI OR DPI IF PATIENT IS TACHYPNEIC
48
Medication delivery to Larger airways
1. Inhale at tidal volume 2. Inhale at a normal or slow speed 3. breathe a normal pattern
49
Medication delivery to smaller airways
1. Inhale through mouth 2. inhale slowly 3. Take a deep breath and hold it for a few seconds
50
Large volume Nebulizers
Useful when traditional dosing isn't working Large volume reservoirs continuous neb (heart) can be hooked to iv pump and premixed drip in a standard reservoir Potential problem and main concern with LVN: drug reconcentration
51
4 other types of nebulizers
Breath enhanced nebulizers Breath actuated nebulizers Vibrating mesh nebulizer Ultrasonic nebulizers
52
Breath enhanced nebulizer
Breath enhanced nebulizers--- generate aerosol continuously, using vents and valves to reduce the aerosol waste
53
Breath actuated nebulizer
Breath actuated nebulizers--- synchronize aerosol generation with the inspiratory effort of the patient reducing the waste of aerosol; GIVE MORE MEDS TO PATIENTS; ENVIRONMENT IS LESS CONTAMINATED.
54
vibrating mesh nebulizer
active or passive based on design can generate aerosol from small drug concentration does not generate much flow particle size created small
55
ultrasonic nebulizer (small)
Piezoelectric crystal to generate aerosol Uses crystal transducer convert to a higher frequency creates less residual drug volume can be portable
56
Goals of bland aerosol therapy
***No medication/ only water/ only saline ``` Bronchial hygiene hydrate dried secretions promote cough restore mucous blanket humidity inspired gas induce sputum ```
57
Hazards of bland aerosol therapy
rehydrated secretions causing airway obstruction bronchospasm or wheezing cross-contamination patient discomfort infection
58
Large volume jet nebulizer (heated)
Pneumatically powered, attached flow meter, and gas source a small jet orifice impacting surfaces baffles decrease large particle remaining small particles leave nebulizer Heating increases water content **NOT USED FOR MEDICATION** **HEATING MEDICINE DEGRADES IT**
59
What to consider when selecting aerosol delivery system?
``` age, physical and cognitive abilities patient preference (more important for home use) availability of drug convenience and durability cost and reimbursement ```