Bronchodilator: Muscarinic Antagonist Flashcards
How do muscarinic antagonists work?
- inhibit muscarinic receptors
- ⬇️ ACh effects
Which short acting muscarinic drug do we need to know about?
- Ipratropium bromide
Ipratropium bromide is a muscarinic antagonist, which muscarinic receptor do short acting muscarinic antagonists (SAMA) target, and which GCPR is present?
- M3 receptors
- Gaq
Ipratropium bromide is a muscarinic antagonist of M3, how long can these drugs take to alleviate symptoms and last for?
- 30 minutes effective
- 6 hours lasting
Is ipratropium bromide, a muscarinic antagonist, given as an inhaler or intravenously?
- generally inhaler
Is ipratropium bromide, a muscarinic antagonist, given as a daily inhaler for asthma and COPD?
- just COPD
When is Ipratropium bromide, a muscarinic antagonist, given to asthma and COPD patients?
- during acute exacerbation
- given as nebuliser
Are SAMA or SABA a more effective bronchodilator?
- SABA
In addition to acting as a bronchodilator ipratropium bromide, a muscarinic antagonist, can also help with what in the lungs?
- reduce mucus production
- enhance mucociliary escalator
Why can the use of SABA and SAMA be effective?
- SABA enhances sympathetic
- SAMA reduces parasympathetic
Which long acting muscarinic antagonist (LAMA) drug do we need to know about?
- Tiotropium
Tiotropium is a long acting muscarinic antagonist (LAMA), by inhibiting muscarinic receptors, what effects do they have on the lungs?
- cause bronchodilatation
- ⬇️ bronchospasm
- ⬇️ mucus production
Tiotropium is a muscarinic antagonist, how long can this drugs last for?
12-24 hours
Is tiotropium, a muscarinic antagonist, given as an inhaler or intravenously?
- generally as an inhaler
Is Tiotropium, a muscarinic antagonist, given as a daily inhaler for asthma and COPD?
- just COPD
