Breast SCORE

Question 1

Large cells with pale cytoplasm and prominent nucleoli describes what breast dx?

Answer 1

Pagets

Question 2

Majority of women with Paget’s dx of breast have an associated what?

Answer 2

infiltrating or intraductal carcinoma

Question 3

What marker distinguished LCIS, lobular hyperplasia and invasive lobular cancer?

Answer 3

reduced E-cadherin expression

Question 4

Li-Fraumeni syndrome; what tumor marker ?

Answer 4

p53

Question 5

Multiple family members that have osteosarcoma, soft tissue sarcomas, lymphoma, brain tumors, breast ca?

Answer 5

Li-fraumeni syndrome

P53 mutation

Question 6

BRC1 and BRC2 located on what chromosomes?

Answer 6

17 & 13 respectively

Question 7

A fibroelastic core that pulls and distorts the ducts is consistent with what?

Answer 7

radial scars

Question 8

What are angiosarcomas of breast?

Answer 8

secondary tumors that arise from dermis of breast after radiation therapy

Question 9

Dark purple nodule arising from field of prior radiation?

Answer 9

angiosarcoma of breast

Question 10

Angiosarcomas of breast that arise from dermis of prior irradiated breast tissue; how do they spread?

Answer 10

blood

no need for lymph node dissection