breast neoplasm Flashcards
which lesions carry a great risk for developing invasive breast carcinoma?
atypical ductal hyperplasia
2nd most common invasive breast carcinoma, which contains loss of E-cadherin?
atypical LOBULAR hyperplasia
a 65 yr old woman is found to have a 1cm mass in the upper outer quadrant of the left breast ?
carcinoma (malignant)
a 57 yrs old woman presents with left breast pain. on examination the breast is erythematous, swollen, and warm to touch. there is also dimpling of the breast (peu d’orange) + the left nipple is completely retracted?
inflammation carcinoma
a 27 yr old woman requested a mamography bcz both her mother and sister died of metastatic breast cancer before 40 yrs of age. what factors determine a risk for breast cancer?
BRCA-1 mutation
. Calcifications frequently are associated
with ……….
DCIS ductal carcinoma in situ
…………..develops when axillary lymph node dissection injuries and obstructs the lymph ducts
lymphedema
what are the causes of edema: lymphatic obstruction ?
inflammation
neoplasia
post-surgical situation
post-radiation situation
Approximately one-third of women with ………… eventually develop
invasive carcinoma.
LCIS lobular carcinoma in situ
The distinctive comedo subtype is characterized by extensive central necrosis, which produces toothpaste like necrotic
tissue that extrudes from transected ducts on application of
gentle pressure in which type of tumor?
DCIS ductal carcinoma in situ
a 45 yr old male patient is admitted with left nipple discharge. on physical examination, an area of 2cm firm area is palpated close to the left nipple. in mammography, BI-RADS 5 masses are defined. invasive cancer is reported. diagnosis?
invasive ductal carcinoma
a 62 yr old female undergoes modified radical mastectomy for invasive carcinoma. best for the patient with low proliferative in the tumor in the histopathology report. what is the expected prognosis?
HER2 -ve (low proliferation) / ER+ve / PR+ve
loss of E-cadherin is found in?
lobular carcinoma in situ & atypical lobular hyperplasia
what are the risk factors for developing breast cancer?
-early age of menarche
-nulliparity
-absence of breast feeding
-older age at first pregnancy
-alcohol
-postmenopausal obesity
-postmenopausal hormone replacement
………….gene mutation is associated with ER positive tumors.
…………..gene mutation is associated with triple negative cancers
BRCA 2
BRCA 1
breast cancers that overexpress ………. gene are highly proliferative
HER2
the survival of patients with ER……..
cancers is higher than patients with ER………. cancers 5
years postdiagnosis, especially for Stages III and IV
positive
negative
which type of non-invasive breast carcinoma are these:
………….. distorts lobules into duct like spaces?
………….. expands involved lobules?
ductal carcinoma in situ
lobular carcinoma in situ
-solid type
-comedo type
-cribriform type
-papillary type
-micropapillary type
-“clinging” type
those are all histological appearances of which type of non-invasive carcinoma
ductal carcinoma in situ
ductal carcinoma in situ–> ………….–> extension into the skin of the nipple causing unilateral crusting exudate and eczema over the nipple and areolar skin
paget disease
……………. is associated with with ductal carcinoma in situ (non-invasive)(precancerous lesion)
invasive (infiltrative carcinoma)
…………….. has a desmoplastic response: replaces normal breast fat with hard, palpable irregular masses)
invasive (infiltrative) carcinoma
which type of carcinoma shows bilateral, indian file cells and dense stroma?
(invasive) lobular carcinoma
