Breast + Endometrial + Ovarian Cancer Flashcards
Definition of early stage breast cancer (Stage I or II)
Tumour <4cm
AND
Node negative on pre-operative workup
Definition of locally advanced breast cancer (stage III)
Tumour >4cm
OR
Node positive on pre-op work up
Most favourable breast cancer receptor status
ER/PR positive
HER2 negative
Treatment of Early Stage Breast Cancer
- What is the standard of care
- 4 reasons to pick mastectomy
- What to next if sentinel node biopsy is positive
Endocrine therapy is still the mainstay of adjuvant therapy for HR-positive, HER2-negative early breast cancer.
T-DM1 most notable SE
Thrombocytopenia!
Risks of Cancer in BRCA1 female carriers
Risk of cancer in BRCA2 female carriers
Male BRCA1 or 2 carrier recommendations
ER Positive Endocrine Treatments in Breast Ca
SERM - selective estrogen receptor modulator
Is mastectomy equivalent to WLE in early stage breast cancer
Yes
Tamoxifen
Actually INCREASE BMD
Aromatase inhibitors
give with a bisphosphonate!
PARP Inhibitors
Pathological Types of Endometrial Ca
Treatment of Cervical Ca
Breast Cancer Screening
Clinical RF of Hereditary Breast Ca
What to offer BRCA patients
Chemotherapy agents of early stage breast Ca
- Names/Classes
- Main short and long term toxicities
Doxorubicin cardiotoxicity is generally irreversible
Surgical Management of Early Breast Ca
DCIS vs LCIS
BRCA 1 female carrier recommendations
Lifetime risk of Cancer in BRCA1 or BRCA2 positive males
Treatment of Ovarian Cancer
Endometrial Cancer Risk Factors
- biggest risk factors
- 3 major other risk factor/type
HER2+ early stage Breast Ca adjuvant treatment:
Cardiomyopathy caused by Trastuzumab is reversible
Treatment of Metastatic Breast Ca
Late recurences are a feature of what type of breast ca?`
Hormone receptor positive breast cancer - particularly in bone
Strongest poor prognostic marker in breast cancer
Pathological Types of Ovarian Cancer
BRCA2 female carrier recommendations
Presentation, Dx and Treatment of Endometrial Ca
What are the indications for chemo in early stage breast ca?
- Node Positive cancer
- High risk features which can be applied to node negative tumours - grade 3, extensive PVI, size >4cm, weak ER/PR expression
Staging of Endometrial Ca
