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Oncology > Breast + Endometrial + Ovarian Cancer > Flashcards

Breast + Endometrial + Ovarian Cancer Flashcards

1
Q

Definition of early stage breast cancer (Stage I or II)

A

Tumour <4cm
AND
Node negative on pre-operative workup

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2
Q

Definition of locally advanced breast cancer (stage III)

A

Tumour >4cm
OR
Node positive on pre-op work up

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3
Q

Most favourable breast cancer receptor status

A

ER/PR positive
HER2 negative

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4
Q

Treatment of Early Stage Breast Cancer

  • What is the standard of care
  • 4 reasons to pick mastectomy
  • What to next if sentinel node biopsy is positive
A

Endocrine therapy is still the mainstay of adjuvant therapy for HR-positive, HER2-negative early breast cancer.

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5
Q

T-DM1 most notable SE

A

Thrombocytopenia!

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6
Q

Risks of Cancer in BRCA1 female carriers

A
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7
Q

Risk of cancer in BRCA2 female carriers

A
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8
Q

Male BRCA1 or 2 carrier recommendations

A
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9
Q

ER Positive Endocrine Treatments in Breast Ca

A

SERM - selective estrogen receptor modulator

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10
Q

Is mastectomy equivalent to WLE in early stage breast cancer

A

Yes

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11
Q

Tamoxifen

A

Actually INCREASE BMD

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12
Q

Aromatase inhibitors

A

give with a bisphosphonate!

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13
Q

PARP Inhibitors

A
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14
Q

Pathological Types of Endometrial Ca

A
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15
Q

Treatment of Cervical Ca

A
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16
Q

Breast Cancer Screening

A
17
Q

Clinical RF of Hereditary Breast Ca

A
18
Q

What to offer BRCA patients

A
19
Q

Chemotherapy agents of early stage breast Ca

  • Names/Classes
  • Main short and long term toxicities
A

Doxorubicin cardiotoxicity is generally irreversible

20
Q

Surgical Management of Early Breast Ca

A
21
Q

DCIS vs LCIS

A
22
Q
A
23
Q

BRCA 1 female carrier recommendations

A
24
Q

Lifetime risk of Cancer in BRCA1 or BRCA2 positive males

A
25
Q

Treatment of Ovarian Cancer

A
26
Q

Endometrial Cancer Risk Factors

  • biggest risk factors
  • 3 major other risk factor/type
A
27
Q

HER2+ early stage Breast Ca adjuvant treatment:

A

Cardiomyopathy caused by Trastuzumab is reversible

28
Q

Treatment of Metastatic Breast Ca

A
29
Q

Late recurences are a feature of what type of breast ca?`

A

Hormone receptor positive breast cancer - particularly in bone

30
Q

Strongest poor prognostic marker in breast cancer

A
31
Q

Pathological Types of Ovarian Cancer

A
32
Q

BRCA2 female carrier recommendations

A
33
Q

Presentation, Dx and Treatment of Endometrial Ca

A
34
Q

What are the indications for chemo in early stage breast ca?

A
  • Node Positive cancer
  • High risk features which can be applied to node negative tumours - grade 3, extensive PVI, size >4cm, weak ER/PR expression
35
Q

Staging of Endometrial Ca

A
36
Q
A

Oncology (9 decks)

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