Breast Disorders Flashcards
The proportion of women that will be diagnosed with breast cancer in their life?
1/8
Where does breast cancer usually metastasize
Genetics of Breast Cancer
Primary Risk Factors of Breast Cancer?
Reproductive/Physical/Lifestyle Risk Factors for Breast Cancer
Invasive Ductal vs. Invasive Lobular Carcinoma?
Molecular factors impacting Breast Cancer?
Principles of screening for a disease
- Disease screened for represents an important health problem
- It has a well-understood natural history
- It has a recognizable early stage
- There is a benefit to early treatment
- There is a suitable test
- There are adequate facilities to diagnose and treat the condition
- Screen can be done at intervals to match the natural history
- There is less harm than benefit
Screening for Breast Cancer
Imaging for Breast Cancer
Types of biopsy for Breast Cancer
Core biospies have largely replaced fine needle aspiration cytology due to the addition information provided by core biopsy (Architecture of lesion/ Cellular appearance)
Staging of Breast Cancer?
TNM classification, based on tumour size, number of nodes involved and evidence of distant metastases
T Staging
- T1: <2cm
- T2: 2-5cm
- T3: > 5cm
- T4: extends to skin/chest wall
N Staging
- N0: No Nodes
- N1: Mobile Ipsilateral Nodes
- N2: Fixed Ipsilateral Nodes
- N3: Infra/supra clavicular or internal mammary nodes
M Staging
- M0: No distant disease
- M1: Distant Disease
Indications for Mastectomy?
- Lcoally advanced tumours
- Large tumour to breast volume ration
- Central tumours involving nipple
- Recurrent breast cancer
- Multifocal or widespread
Various forms of mastectomy available
Indications for Sentinel Lymph node biopsy (SLNB) in breast cancer?