Breast Benign Tumors/Fibrocystic Changes

Question 1

Fibrocystic Change (demographic, gross)

Answer 1

Most common change in premenopausal breast, blue dome appearance

Question 2

Different Fibrocystic Changes (overall and 3-6 specific) and Cancer Risk

Answer 2

Overall benign, but some have increased risk for cancers (in both breasts, not just observed)

1. Fibrosis, cysts, and APOCRINE METAPLASIA - NO RISK
2. Ductal hyperplasia and sclerosing adenosis (too many glands. Often calcified) - some risk
3. Atypical hyperplasia - 5x increased risk

Question 3

Intraductal Papilloma Presentation, and Histo/Age Differentiation with Papillary Carcinoma

Answer 3

Bloody nipple discharge in premenopausal women (carcinoma is post). Has BOTH luminal and myoepithelial cell layers, as opposed to carcinoma having just luminal

Question 4

Intraductal Papilloma Presentation, and Histo/Age Differentiation with Papillary Carcinoma

Answer 4

Bloody nipple discharge in premenopausal women (carcinoma is post). Has BOTH luminal and myoepithelial cell layers, as opposed to carcinoma having just luminal

Question 5

Fibroadenoma Demographic/Presentation, Hormones, Cancer Risk

Answer 5

Most common tumor in premenopausal, well circumscribed marble like mass
E sensitive so grows in pregnancy and maybe painful in menstrual cycle
Benign. No risk of cancer

Question 6

Phyllodes Tumor

Answer 6

Fibroadenoma-like mass with overgrowth of fibrous component so get “leaf-like” projections. Usually postmenopausal and can be malignant