Brain Development Flashcards

1
Q

Which germ layers leads to the formation of the nervous system and the skin?

A

The ectoderm

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2
Q

When does the brain begin to form?

A

At three weeks of development

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3
Q

What is the neural plate?

A

Tissue from the ectoderm that goes to form the nervous system. It first folds in on itself to form the neural tube.

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4
Q

What is the role of somites?

A

Protection of the notochord and the spinal cord.

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5
Q

What determines the fate and position of the cell?

A

Chemical compounds called morphogens and their concentration. They are secreted by the notochord.

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6
Q

What are the 6 processes of neural development?

A
  1. Proliferation
  2. Migration
  3. Aggregation
  4. Differentiation
  5. Circuit formation
  6. Pruning and programmed cell death.
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7
Q

When does myelination occur?

A

Following synaptic pruning

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8
Q

What is neurogenesis?

A

Neural proliferation

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9
Q

What is symmetric division in terms of neuronal proliferation?

A

Cortical progenitor cells divide two produce either two progenitor cells, which predominate during earlier stage of neurogenesis, or two new neurons, which occur during later stages of neurogenesis.

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10
Q

Where does proliferation occur?

A

In the ventricular and subventricular zones

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11
Q

What are the two types on neural migration?

A

Radial migration and tangential migration.

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12
Q

What is radial migration?

A

Ventricle neural precursors climb up the radio glial cells to the dorsal surface of the cortical plate. Those that arrive first form the inner layer (5).

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13
Q

What is tangential migration?

A

Neurons from the ganglion eminence migrate freely to the dorsal surface of the cortical plate where they become interneurons.

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14
Q

How is the axon formed and stretched out during polarisation of the neuron?

A

Morphogens aid polarisation. Chemo-attractants and chemo-repellents guide the axon to stretch in the appropriate direction.

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15
Q

How are synapses formed in terms of the chemo-attractant process?

A

Presynaptic and postsynaptic proteins attract each other to form synapses.

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16
Q

Can synaptic connections re-establish following pruning?

A

Yes

17
Q

What is a critical period?

A

Period of brain development during which the brain is susceptible to abnormalities due to mutations and environmental insults.