Bradley: Antidepressants Flashcards
SSRIs: Paroxetine
PTSD, short half-life can set stage for withdrawal
SSRIs: Fluoxetine
Very long half-life, prevents withdrawal
SSRIs: Citalopram
QTc prolongation
SSRIs: Escitalopram
QTc prolongation
S isomer, more biologically active
SSRIs: Nefazodone
Irreversible liver toxicity
SNRIs: Atomoxetine
ADHD
SNRIs: Duloxetine
Fibromyalgia, pain and depression
SNRIs: Venlafaxine
Effexor –> Most effective anti-depressant
Severe withdrawals: Shock parasthesias
TCAs/SNDRIs: Amitriptyline
Pain, migraine, eye pain
TCAs/SNDRIs: Clomipramine
FDA approved OCD
TCAs/SNDRIs: Doxepin
Antihistaminic for hives, insomnia
TCAs/SNDRIs: Imipramine
FDA approved for enuresis (bedwetting)
TCAs/SNDRIs: Protriptyline
Least sedating
MAOIs: Phenylzine
Non-selective MAOI (A and B)
AND
Irreversible (enzyme permanently inhibited until body make more)
MAOIs: Isocarboxazid
Non-selective MAOI (A and B)
AND
Irreversible (enzyme permanently inhibited until body make more)
MAOIs: Tranylcytopromine
Non-selective MAOI (A and B)
AND
Irreversible (enzyme permanently inhibited until body make more)
MAOIs: Selegiline
Selective for MAO-B
MAOIs inhibit degradation of which monoamine and this monoamine can do what to the body?
Inhibits degradation of Tyramine, which can elevate BP
The Orphans: L-Methyl Folate
Useful for MTHFR insufficiencies
The Orphans: Bupropion
Smoking cessation, sex life okay,
The Orphans: Trazadone
Strongly inhibits post-synaptic alpha receptors
Priaprism, Low BP
The Orphans: Mirtazapine
Somnolence
Increased appetite
Anxiety
Best ‘fit’ for anxiety, insomnia, and decreased appetite
