Bovine Therio - 1 Estrous Cycle and Reproductive Endocrinology Flashcards

1
Q

Bovine are what kind of breeders

A

Non seasonal polycyclic

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2
Q

Bovine female reaches puberty at what age

A

7-18mths (avg. 10mths)

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3
Q

The bovine oestrous cycle length is

A

18-24days (avg. 21days)

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4
Q

The bovine oestrus cycle is divided into two phases, name and define them

A

Luteal phase: 14-18days the period following ovulation when the corpus luteum is formed (met-estrus and diestrus)
Follicular phase: 4-6days the period following the demise of the CL until ovulation (pro-estrus and oestrus)

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5
Q

Bovine oestrous cycle is divided into how much follicular waves and how long does each wave take

A

2-3 follicular waves

7-10days appart

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6
Q

During bovine oestrous cycle, what happens to the ovulatory follicle during the follicular phase

A

Maturation and ovulation, the oocyte is released into the oviduct allowing the potential for fertilization

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7
Q

The bovine oestrous cycle is regulated by hormones from various locations, name them and their location

A

Gonadotrophin-releasing hormone (GnRH) - Hypothalamus
Follicle-stimulating hormone (FSH) & Luteinizing hormones (LH) - Anterior pituitary
Progesterone (P4), Estradiol (E2) & Inhibin - Ovaries
Prostaglandin F2α (PGF) -Uterus

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8
Q

Describe Bovine Luteal phase Metoestrus

  • Day
  • CL?
  • Uterine tone
  • Other?
A

Day 1-4
Ovulation depression > Corpus haemorrhagicum > Early CL
Within 48hrs - CL 1.4cm
Uterus - slight tone/oedema/flaccid
Metoestral bleeding (only occurs in cattle
Ova Transport time 3-4 days

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9
Q

Describe Bovine Luteal phase Diestrus

  • Day
  • Dominant hormone
  • CL
  • Uterine tone
  • Cervix
A
Day 6-18
Progesterone
Palpable papilla (CL)
Flaccid uterus
Cervix closed
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10
Q

In non pregnancy, describe the continuation of follicular development (pro-oestrus)

A

PGF secreted by the endometrium > regression of the CL > fall in progesterone > BPO axis > GnRH > FSH > Follicular development

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11
Q

Describe Bovine Follicular phase Pro-oestrus

  • Day
  • Dominant hormone
  • CL
  • Follicle
  • Uterine tone
  • Vulva
  • Signs
A
Day 19-20
FSH
CL 1.5-2cm
F 1.5-2cm
Moderate uterine tone
Vulva swollen
Signs: slight mucous, mounting behaviour
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12
Q

Describe Bovine Follicular phase Oestrus (prior to ovulation)

  • Day
  • Dominant hormone
  • CL
  • Follicle
  • Uterine tone
  • Cervix
  • Vagina
  • Vulva
  • Signs
A
Day 21
Oestrogens (esp. Estradial) & baseline progesterone (due to regression of CL)
CL 1.5cm
Rapidly growing dominant F
Marked uterine tone
Dilated cervix
Vagina mm pink
Vulval oedema
Signs: thick mucous discharge, oestrus behaviour
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13
Q

What is the duration of bovine oestrus (not oestrous cycle)

A

8-12hrs

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14
Q

When does ovulation occur in the bovine

A

After END of oestrus

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15
Q

When is the best time (best fertility) to AI a bovine

A

Mid-oestrus to few hrs after end of oestrus

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16
Q

Ovulation in the bovine, is the beginning of the oestrus cycle (day 0). Define it.

A

The rupturing of the follicle that releases the ovum

17
Q

The same hormones that control the timing of ovulation in the bovine, control what else

A

Behavioural estrus (heat)

18
Q

Both timing of ovulation and estrus is controlled by the same hormones in the bovine. What hormone is this? Where does it act and why is this important

A

Estradiol on the hypothalamus, uterus and higher brain (behavioural change). Easier to detect optimum fertility

19
Q

After ovulation in the bovine, the ruptured follicle becomes what?

A

Corpus luteum

20
Q

The bovine CL is formed under the influence of what

A

Pituitary LH

21
Q

The bovine CL decides the length of the oestrus cycle?

22
Q

What is the function of the bovine CL

A

Secretion of progesterone

23
Q

The bovine CL is responsive to PGF after how many days

A

5/6

receptors acquired

24
Q

What day does the bovine CL reach max size

A

7-8th CL 2-2.5cm

25
What is the purpose of the progesterone produced by the bovine CL
To establish and maintain pregnancy
26
If bovine pregnancy does not result, another hormone is released which lyse the CL. What is the hormone and where does it come from? And when does it occur
Prostaglandin F2α from uterus at day 17/18
27
What happens when the bovine CL degenerates
Decline in progesterone
28
Following the decline the progesterone in the bovine estrous cycle there is a rise in another. What hormone is this
Increase in Oestrogen (mainly oestradiol-7)
29
When does the peak in Oestrogen during the bovine oestrous cycle occur
Right before onset of oestrus
30
What effect does oestrogen have on the hypothalamus during the bovine oestrous cycle
Stimulates the release of GnRH
31
What is the effect of preovulatory GnRH in the bovine
Stimulates the release of FSH and LH
32
What is the function of FSH in the bovine oestrous cycle
It stimulates a group of follicles to grow (recruitment)
33
What is the function of LH in the bovine oestrous cycle
After recruitment of a group of follicles, LH is responsible for keeping them growing
34
What happens when there is a dominant ovarian follicle in the bovine
It produces estradiol and inhibin
35
What are the functions of estradiol and inhibin secreted by the DF in the ovary in bovines
It prevents the growth of other follicles
36
Estradiol and Inhibin also affect the hypothalamus in what way in the bovine oestrous cycle
Inhibin: decrease FSH Estradiol: Preovalatory LH surge *note progesterone level must be low i.e after CL regression*
37
Remember, there are 2 to 3 follicular waves in the bovine. Which means there is recruitment of follicles several times. Why does this occur?
Because the CL is still present with progesterone and will not allow maturation of the follicle
38
At the last follicular wave during the bovine oestrous cycle, the last bit of estradiol is "squeezed" out by
Oxytocin
39
LH other than stimulating bovine follicle growth is also stimulates.....
Ovulation