Bovine TB

Question 1

What is bovine TB?

Answer 1

Respiratory tract infection of cattle
Zoonotic bacterial disease

Question 2

How is TB transmitted?

Answer 2

• arosol droplets
• ingestion of contaminated milk
• contact with excreations of infected animals
• intracellular

Question 3

How does TB immune evade?

Answer 3

• Highly adapted to intracellular growth
• Evades destruction by innated immune cells through inhibiting maturation of phagloysosome/ escapes phagosome/ replicates within cytoplasmic space
  -inhhabition of mhc 11
  -inhibitory PPRligands
  Resists effects of superoxide
  Interferes with antigen presentation

Question 4

How to control TB?

Answer 4

• no vaccine
• Test and slaughter protocol