Boruchoff - MRSA

Question 1

What part of the body most commonly colonizes MRSA

Answer 1

Nares of the nostrils

Question 2

What can you give to decolonize the nose of. Staph aureus?

Answer 2

Mupirocin - intranasally

Question 3

Mechanism of action of Mupirocin

Answer 3

Binds to isoleucyl tRNA synthetase (ileS), which disrupts protein synthesis.

Question 4

MEchanisms of action of Mupirocin

Answer 4

Point mutation in ileS

Plasmid containing a novel ileS gene called mupA

Question 5

What is a horizontal program? Vertical program??

Answer 5

Horizontal - reduces all infections at a specific anatomical site
Vertical - targets a single organism at that site

Question 6

Tests for MRSA screening?

Answer 6

CHROMagar MRSA - the colonies turn a specific color if it is MRSA positive - in this example it is purple.

Xperia MRSA - basically PCR. It tells you if you have MRSA and how much

Question 7

Recommendations for visitors going to patients in isolation rooms

Answer 7

Hand hygiene

- depends if they are immunosuppressed of not