Bordetella Pertussis Flashcards

1
Q

Characteristics of B. Pertussis x2

A
  • small

- gram -ve cocci

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2
Q

Highly significant in which age groups? What complications could follow?

A

Highly significant in children

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3
Q

Clinical features x3

A
  • insidious onset
  • catarrhal stage with common cold symptoms
  • paroxysmal coughing
  • residual cough
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4
Q

Symptoms of whooping cough

A
  • shortness of breath during coughing
  • nocturnal coughing
  • post-tussive vomitting
  • tingling sensation in back of throat
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5
Q

Mode of action of b. Pertusis

A

The organism infects the ciliated epithelial layer of the respiratory tract without invading deeper, resulting in acute tracheobronchitis

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6
Q

Name 2 things that aid the invasion of the epithelial layer

A

Pertussis toxin

Filamentous hemagglutinin

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7
Q

What is the outer membrane protein that promotes its attachment to tracheal epithelial cells?

A

Pertactin

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8
Q

What is the function of pertactin?

A

It promotes the attachment of bordetella pertussis to tracheal epithelial cells

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9
Q

Name 4 toxins involved with b.pertussis

A
  • pertussis toxin
  • adenylate cyclase / hemolysin
  • tracheal cytotoxin
  • lipopolysaccharide (endotoxin)
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10
Q

Diagnosis of B. Pertussis

A

Hold BG culture plate in front of mouth when coughing

Perinasal swab of posterior pharyngeal walls

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11
Q

Treatment of B. Pertussis

A

Erythromycin for 14 days

Skilled nursing, removal of mucous and vomit

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12
Q

What does bordetella pertussis cause?

A

Whooping cough

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