boosts Flashcards
1
Q
- Joe Bob showed up to school one day irritated after a recent round of vaccinations. To cheer him up one of his friends, Peggy Sue, gave him a peanut butter cookie. His lips became swollen and he had trouble breathing. Upon visiting your clinic, his parents ask you to test him for peanut allergies. A small blood sample is withdrawn and you measure:
A
D. Antigen-specific (peanut) IgE levels.
2
Q
- The disease IPEX is caused by mutations in:
A
D. Foxp3 that is required for T reg development and maintenance.
3
Q
- T regs function by all of the following mechanisms except:
A
D. Induction of receptor editing in extrathymic CD4 cells.
4
Q
- What type I hypersensitivity reaction does not require antibodies?
A
B. Type IV.
5
Q
- APECED is caused by mutations in:
A
Aire mutations that decrease negative selection.
6
Q
- The destruction of beta cells causes which autoimmune disease:
A
D. Type I diabetes.
7
Q
- Which of the following is a diagnostic for SLE?
A
anti-dsDNA antibodies.
8
Q
- Epitope spreading refers to:
A
D. The broadening of the specificity of self responses during autoimmunity.
9
Q
- Cancer cells must:
A
A. Become resistant to apoptosis to cause malignant tumors.
10
Q
- Which of the following is promising strategy to augment anti-tumor immune responses?
A
B. Blocking inhibitory receptor-ligand interactions.
11
Q
A. Blocking inhibitory receptor-ligand interactions.
A
B. Possess the same major and minor histocompatibility antigens.
12
Q
- Direct allorecognition occurs when:
A
C. Host T cells recognize donor HLA on donor DCs
13
Q
- Which of the following deficiencies hinders adaptive immunity directly:
A
C. X-linked agammaglobulinemia.
14
Q
- Loss of which cell type precludes AIDS and death during HIV infection:
A
CD4+ T cells.
15
Q
FK506 and cyclosporine function by:
A
Blocking NFAT nuclear translocation.
