Bone Tumors in Adults

Question 1

Malignant TUmors in Adults

Answer 1

Mets
Myeloma
Lymphoma
Sarcoma

Question 2

Acral Metastasis ( distal to elbow and distal to knee)

Answer 2

Think lung carcinoma

Question 3

Metastasis Osteoclastic Pathway

Answer 3

TGF-B increased PTHrP and decrease OPG,

INcreaes in RANKL

Question 4

Elastofibroma location and stain?

Answer 4

Elastin

Mass deep to serratus anterior

Question 5

Nerve Sheath Tumors Pathonogmnic sign?

Answer 5

Target Sign
Schwanommas : NF2 association , antoniA/Anotni b
Neurofibroma

Neurofibroma is in continuity with nerve and schanomas is on top of hte nerve

Question 6

Neurofibroma Stain?

Answer 6

s100 ( nerve sheath tumor)

Question 7

Mazzabrauds Syndrome?

Answer 7

Polyostotic Fibrous Dysplasia AND AND

INtramuscular Myxomas

Question 8

Atypical Lipomatous Tumor Stain ( ALT)

Answer 8

MDM2

Question 9

Lipoma–>Atypical Lipomatous Tumor–> Liposarcoma

Answer 9

ALTs- Have thickened septa

Question 10

SMA?

Answer 10

Smooth Muscle Actin

Leiomyosarcoma ( smooth muscle tumor)

Question 11

Alveoloar Rhabdomyosarc translocation?

Answer 11

2:13

Question 12

General Treatment for Sarcomas?

Answer 12

radiation and Surgery

Question 13

Radiation for Soft Tissue ?

Answer 13

Does not improve survival but DOES improve local Recurrance

5000cGy pre op
6000cGy post op