Basic Science 2 Flashcards
Maximum Length that can be bridged by nerve conduit?
3cm
Following Peripheral nerve injry, distal recovery typically occurs first in____
Sympathetic Activity
Freeze dried versus Frozen allograft?
Freeze dried has reduced torsional and bening strenth compared to frozen
Fondaparinux MOA?
Indirect Factor X (10)inhibitor
Which biomaterial has highest rate f=of bacterial adherence?
Titanium Alloy
12:16 (t)
Myxoid liposarcoma
Long Term malignant sarcoma after GCT?
Fibrosarcoma, p53 mutation
BMP receptor ?
Serine/threonine kinase
BMP 2 uses ?
Open tibia
ALIf
BMP7 uses ?
BMP 3 NOT osteoinductive
Tibial Non unions
Revision spine PL fusions
FGF receptor ?
Tyrosine kinase
PPAR- Gamma MOA?
Adipogenic differentiation
Stages of Hemodynamics Shock and Blood Loss ?
1 -<15% all normal
2- 15-30 HR elevated
3- 30-40 Hr elevated , decrease BP >120bpm
4 >40
Wht action does thrombin do and what is a direct thrombin inhibitor ?
Thrombin converts fibriniogen to fibrin
Dabigatran is direct thrombin inhibitor
What is the extracellular matrix protien involved in the organization of collegan?
Decorin
What is Northern blot used for detection of?
RNA
Herringbone bpattern cancer type?
Fibrosarcoma
Typical locaiton of
- Fibrous Dysplasia?
- Osteofibrous Dysplasia?
- Proximal femur (Gs- Alpha mutation
2. Anterior cortex of diaphysial tibia
Epithelial cells in glandular pattern separated by fibrous stroma?
Adamantinoma
Treatment is Wide resection
What syndrome is fibrous dysplasia associated with?
McCune Albright
- Precocious puberty, fibrous dysplsia,
Jagged cafe au lait spots (coast of maine)
What drug should you NOT use if D-Zone test is positive?
Clindamycin
Chondroblastoma typical location and age?
Epiphyseal location in young adults
Ubiquitin Specific Protease 6 is associated with what lesion ?
Anuerysmal bone Cyst
When is it too late for MUA for TKA?
Usually after 12 weeks
- Need 105d of motion for ADLS
Anakinra MOA?
IL-1 antagonists
What malignant transformation does NF have?
Neurofibromas into Malignant peripheral nerve sheath tumors
What mediator is pathologically activated in the formation of osteophytes in OA?
Indian HedgeHog
reciever operator curve (ROC). What dtermines the accuracy?
A larger area under the curve
