Basic Science 2

Question 1

Maximum Length that can be bridged by nerve conduit?

Answer 1

3cm

Question 2

Following Peripheral nerve injry, distal recovery typically occurs first in____

Answer 2

Sympathetic Activity

Question 3

Freeze dried versus Frozen allograft?

Answer 3

Freeze dried has reduced torsional and bening strenth compared to frozen

Question 4

Fondaparinux MOA?

Answer 4

Indirect Factor X (10)inhibitor

Question 5

Which biomaterial has highest rate f=of bacterial adherence?

Answer 5

Titanium Alloy

Question 6

12:16 (t)

Answer 6

Myxoid liposarcoma

Question 7

Long Term malignant sarcoma after GCT?

Answer 7

Fibrosarcoma, p53 mutation

Question 8

BMP receptor ?

Answer 8

Serine/threonine kinase

Question 9

BMP 2 uses ?

Answer 9

Open tibia

ALIf

Question 10

BMP7 uses ?

BMP 3 NOT osteoinductive

Answer 10

Tibial Non unions

Revision spine PL fusions

Question 11

FGF receptor ?

Answer 11

Tyrosine kinase

Question 12

PPAR- Gamma MOA?

Answer 12

Adipogenic differentiation

Question 13

Stages of Hemodynamics Shock and Blood Loss ?

Answer 13

1 -<15% all normal
2- 15-30 HR elevated
3- 30-40 Hr elevated , decrease BP >120bpm
4 >40

Question 14

Wht action does thrombin do and what is a direct thrombin inhibitor ?

Answer 14

Thrombin converts fibriniogen to fibrin

Dabigatran is direct thrombin inhibitor

Question 15

What is the extracellular matrix protien involved in the organization of collegan?

Answer 15

Decorin

Question 16

What is Northern blot used for detection of?

Answer 16

RNA

Question 17

Herringbone bpattern cancer type?

Answer 17

Fibrosarcoma

Question 18

Typical locaiton of

1. Fibrous Dysplasia?
2. Osteofibrous Dysplasia?

Answer 18

1. Proximal femur (Gs- Alpha mutation

2. Anterior cortex of diaphysial tibia

Question 19

Epithelial cells in glandular pattern separated by fibrous stroma?

Answer 19

Adamantinoma

Treatment is Wide resection

Question 20

What syndrome is fibrous dysplasia associated with?

Answer 20

McCune Albright
- Precocious puberty, fibrous dysplsia,
Jagged cafe au lait spots (coast of maine)

Question 21

What drug should you NOT use if D-Zone test is positive?

Answer 21

Clindamycin

Question 22

Chondroblastoma typical location and age?

Answer 22

Epiphyseal location in young adults

Question 23

Ubiquitin Specific Protease 6 is associated with what lesion ?

Answer 23

Anuerysmal bone Cyst

Question 24

When is it too late for MUA for TKA?

Answer 24

Usually after 12 weeks

- Need 105d of motion for ADLS

Question 25

Anakinra MOA?

Answer 25

IL-1 antagonists

Question 26

What malignant transformation does NF have?

Answer 26

Neurofibromas into Malignant peripheral nerve sheath tumors

Question 27

What mediator is pathologically activated in the formation of osteophytes in OA?

Answer 27

Indian HedgeHog

Question 28

reciever operator curve (ROC). What dtermines the accuracy?

Answer 28

A larger area under the curve