Basic Science 2 Flashcards

1
Q

Maximum Length that can be bridged by nerve conduit?

A

3cm

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2
Q

Following Peripheral nerve injry, distal recovery typically occurs first in____

A

Sympathetic Activity

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3
Q

Freeze dried versus Frozen allograft?

A

Freeze dried has reduced torsional and bening strenth compared to frozen

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4
Q

Fondaparinux MOA?

A

Indirect Factor X (10)inhibitor

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5
Q

Which biomaterial has highest rate f=of bacterial adherence?

A

Titanium Alloy

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6
Q

12:16 (t)

A

Myxoid liposarcoma

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7
Q

Long Term malignant sarcoma after GCT?

A

Fibrosarcoma, p53 mutation

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8
Q

BMP receptor ?

A

Serine/threonine kinase

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9
Q

BMP 2 uses ?

A

Open tibia

ALIf

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10
Q

BMP7 uses ?

BMP 3 NOT osteoinductive

A

Tibial Non unions

Revision spine PL fusions

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11
Q

FGF receptor ?

A

Tyrosine kinase

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12
Q

PPAR- Gamma MOA?

A

Adipogenic differentiation

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13
Q

Stages of Hemodynamics Shock and Blood Loss ?

A

1 -<15% all normal
2- 15-30 HR elevated
3- 30-40 Hr elevated , decrease BP >120bpm
4 >40

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14
Q

Wht action does thrombin do and what is a direct thrombin inhibitor ?

A

Thrombin converts fibriniogen to fibrin

Dabigatran is direct thrombin inhibitor

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15
Q

What is the extracellular matrix protien involved in the organization of collegan?

A

Decorin

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16
Q

What is Northern blot used for detection of?

17
Q

Herringbone bpattern cancer type?

A

Fibrosarcoma

18
Q

Typical locaiton of

  1. Fibrous Dysplasia?
  2. Osteofibrous Dysplasia?
A
  1. Proximal femur (Gs- Alpha mutation

2. Anterior cortex of diaphysial tibia

19
Q

Epithelial cells in glandular pattern separated by fibrous stroma?

A

Adamantinoma

Treatment is Wide resection

20
Q

What syndrome is fibrous dysplasia associated with?

A

McCune Albright
- Precocious puberty, fibrous dysplsia,
Jagged cafe au lait spots (coast of maine)

21
Q

What drug should you NOT use if D-Zone test is positive?

A

Clindamycin

22
Q

Chondroblastoma typical location and age?

A

Epiphyseal location in young adults

23
Q

Ubiquitin Specific Protease 6 is associated with what lesion ?

A

Anuerysmal bone Cyst

24
Q

When is it too late for MUA for TKA?

A

Usually after 12 weeks

- Need 105d of motion for ADLS

25
Anakinra MOA?
IL-1 antagonists
26
What malignant transformation does NF have?
Neurofibromas into Malignant peripheral nerve sheath tumors
27
What mediator is pathologically activated in the formation of osteophytes in OA?
Indian HedgeHog
28
reciever operator curve (ROC). What dtermines the accuracy?
A larger area under the curve