Bone Pathology Flashcards

1
Q

What structures/type of tissue forms during the inflammatory phase of bone healing?

A

Haematoma

Granulation tissue

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1
Q

How long do fractures take to repair in children?

A

Around half the usual time

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2
Q

What is the difference between complete and incomplete fractures?

A

Complete is when the whole shaft of a bone is separated

Incomplete is were it isn’t complete separated

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2
Q

What is the underlying cause of osteomalacia?

A

Vitamin D deficiency

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3
Q

What is a stress fracture?

A

A fracture caused by repeated low force injuries to a bone

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4
Q

If the ends of a fracture are closely apposed, which stage of repair can be skipped?

A

The soft callus stage

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5
Q

What are the two effects that bone mets can have on the structure of bone?

A

Osteolytic

Osteosclerotic

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6
Q

How long is the hard callus stage usually?

A

Weeks to months

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8
Q

What mechanotransduction?

A

The ability of osteocytes to sense stresses present in bone

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8
Q

What is pseudo-arthrosis?

A

Fibrous tissue that forms in a non-union joint in place of proper repair

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9
Q

What are some bones that are commonly affected by avascular necrosis?

A

Head of femur

Scaphoid

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10
Q

What is the new name for a simple fracture?

A

Closed fracture

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11
Q

What is a displaced fracture?

A

When the two ends of a fracture no longer communicate

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13
Q

Which cells of the bone produce ALP (alkaline phosphatase)?

A

Osteoblasts

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14
Q

What are the goals of treatments intervention with fractures?

A

Close the gap between fracture ends

Reduce movement

Remove factors that slow healing eg poor blood supply, infection, smoking

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15
Q

What determines the severity of osteoporosis?

A

Peak bone mass

Resorption - begins >30

16
Q

What is the pathophysiology of Paget’s disease?

A

Osteoclasts are over-reactive

Osteoblasts produce more bone

Results in thick, soft cortical bone, rough trabecular bone and ease of fractures

17
Q

What is a pathological fracture?

A

When the fracture is due to some underlying pathology eg osteoporosis or mets

17
Q

How does hyperparathyroidism effect bone cells?

A

Increases the activity of osteoclasts

18
Q

What is the new name for a compound fracture?

A

Open

20
Q

How long does it take for non-union fractures to heal?

A

They don’t

21
Q

What is a comminuted fracture?

A

When there are more than 2 broken pieces

22
Q

A butterfly fracture is another name for what type of fracture?

A

Comminuted

23
Q

Despite being thicker than normal, why is the hard callus weaker than normal bone?

A

Because it’s made up of woven bone

24
Q

How long does the remodelling stage take?

A

Months to years

26
Q

What is mal-union?

A

Healing of a bone in an unacceptable position

27
Q

What are the 4 stages of bone healing?

A

Inflammatory phase

Reparative phase

  • Soft callus (cartilage is laid down)
  • Hard callus (cartilage is replaced by bone)

Remodelling phase - woven bone is remodelled into Haversian systems

28
Q

How long does a typical upper limb fracture take to repair in a adult?

A

6-8 weeks