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MI Clinical Diagnosis > Bone, Joint, Collagen > Flashcards

Bone, Joint, Collagen Flashcards

1
Q

what are the clinical features of RA

A 
slow onset 
chronic 
polyarticular - hands/feet 
small joints 
low grade fever 
myalgia 
malaise 
fatigue 
systemic - heart and lungs
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2
Q

what are the lab features of RA

A

anemia present
WBC normal or increase
RF/RA factor
Anti CCP

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3
Q

what percent of people with RA have anemia

A

40% of men

60% of women

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4
Q

in 3% of RA cases, what other problems occur

A

leukopenia
splenomegaly
RA

= Feltys Syndrome

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5
Q

how sensitive is RA/RF factor for rheumatoid arthritis

A

85%

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6
Q

how sensitive is anti CCP for rheumatoid arthritis

A

95%

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7
Q

what are the seronegative spondyloarthropathies also called

A

rheumatoid variants

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8
Q

what are the clinical features of AS

A

spine and SI joints
extremities - 30%
males common

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9
Q

what are the lab features of AS

A

ESR increase 90%

HLA-B27 - not diagnostic

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10
Q

what are the clinical features of psoriatic arthritis

A

DIP joints

spine 20%

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11
Q

what percent of psoriatics develop arthritis

A

10%

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12
Q

what are the clinical features of reiters syndrome

A 
arthritis 
urethritis - non GC 
conjuctivitis 
iritis 
mucocutaneous oral ulcers
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13
Q

what are the clinical features of arthritis associated with IBD

A

20% of IBD develop migratory, lower extremity, peripheral joint disease

sacroilitis 15%

iritis is common

spondylitis 5%

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14
Q

iritis is common in what 2 arthritidies

A

reiters syndrome
and
enteropathic/IBD

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15
Q

enteropathic/IBD arthritis commonly affects what joints

A

knee and ankle

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16
Q

acute rheumatic fever is caused by what

A

group a beta hemolytic strep

hypersensitivity reaction after infection of GABHS

17
Q

what are the aggregations of histiocytes called in acute rheumatic fever

A

aschoff bodies

18
Q

what are the clinical features of acute rheumatic fever

A

fever
migratory arthritis
cardiac damage
renal damage

19
Q

what is the ASO titer used for

what are the values that may indicate or that are diagnostic of the disease

A

GABHS

> 200 = indicative of recent strep infection

> 500 = diagnostic for disease

20
Q

what are the lab values of acute rheumatic fever

A

ASO titer
>200 - indicates strep
>500 - diagnostic

ESR elevated

21
Q

what is a extremely painful and immobilizing form of arthritis

A

gout

22
Q

what are the clinical features of gout

A

painful
monoarticular
affects big toe

23
Q

what part of the body does gout rarely affect

A

spine

24
Q

what causes gout

A

uric acid accumulation from purine synthesis

increased intake of purines - doesnt cause gout - may worsen tho

decreased excretion of uric acid

increased production of uric acid

25
Q

decreased secretion of uric acid can be caused by what

A 
renal insufficiency 
thiazide diuretics 
ketoacidosis 
alcoholism 
hypothyroidism
26
Q

increased production of uric acid can be caused by what

A 
hypermetabolic syndromes 
myeloproliferative syndrome 
leukemia 
polycythemia vera 
malignancy 
chemo or radiation 
hemolytic anemia 
diabetes 
sarcoidosis
27
Q

what are a defined group of diseases exhibiting necrosis of collageneous tissue and inflammatory arterial disease

A

collagen vascular disease

28
Q

what are the clinical features of collagen vascular diseases

A

myalgia
fatigue
headache
stiffness

29
Q

what are examples of diseases in the group of collagen vascular diseases

A 
progressive systemic sclerosis (PSS) 
mixed connective tissues disease (MCTD)
sjorgens syndrome 
temporal arteritis 
SLE
30
Q

what does ANA indicate

A

any autoimmune disorders

SLE, MTCD, PSS, RA, scleroderma, sjorgens

31
Q

ANA is 95% sensitive for what autoimmune condition

A

SLE

32
Q

anti DNA is found in what conditions

A

SLE 60-80% (anti DNA ds)

rare in all other autoimmune disorders

33
Q

what are the two subtypes of anti DNA

A

double strand ds

single strand ss

34
Q

which subtype of anti DNA is found in SLE

A

double strand anti DNA

ds

35
Q

anti ENA is found in what conditions

A

SLE and MCTD

not found in any other autoimmune conditions

36
Q

what does anti ENA stand for

A

anti extractable nuclear antigen

37
Q

anti scleroderma 70 is DIAGNOSTIC for what condition

A

PSS

MI Clinical Diagnosis (12 decks)

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