Bone and cartilage Flashcards
What is the average bone mineral density in these different sports:
Runners, gymnastics, track, hockey, soccer, swim.
- Runners = 1.079
- gymnastics = 1.173
- track = 1.152
- hockey= 1.161
- swim = 1.083
Why do runners and swimmers have a lower density?
swimming is weight supportive and running doesn’t involve impact to upper body. Less stress = less BMD.
List the factors that shape the bone re-modelling response.
Weight bearing Magnitude of load Rate of loading Direction of forces Volume of loading Pull of tendons on bone.
What do the osteoblasts do?
Form bone tissue
What do the osteocytes do?
Maintain bone tissue
What do the osteoclasts do?
Functions in resorption, the destruction of bone matrix.
What is the turnover rate of the bone remodelling process?
5-7% per week
How long until the skeleton is completely replaced?
every 10 years
How many days is the total cycle for compact bone?
100 days
What % of compact bone is replaced each year?
5%
How many days is the total cycle for spongy bone?
200 days
What % of spongy bone is replaced each year?
25%
What are the stages of bone remodelling process?
- resting
- resorption
- reversal
- formation
- mineralisation
What bone cells are involved in resorption?
osteoclasts
What cell is involved in reversal?
macrophage
What cell is involved in formation?
Osteoblast
What cell is involved in mineralisation?
Osteocytes. Osteoblasts line cell to stop osteoclast getting to bone underneath.
What is the incomplete cellular layer of the bone called?
Endosteum - deep layer
What does the endosteum contain?
Osteoblasts, osteoprogenitor cells and osteoclasts.
What is the outside layer of the bone called?
Periosteum
What does the Periosteum contain?
Outer (fibrous) and inner (cellular) layers
What bone cell is on the periosteal and endosteal surface?
Osteoblasts
What bone cell is just on the endosteal surface?
Osteoclasts
How can osteoblasts and osteoclasts change thickness of the bone?
By up or down regulation from the inside and the outside.