Body Fluid Compartments Flashcards
1
Q
What is the distribution if the Vd of a drug is < 3 L?
A
Plasma only
2
Q
What is the distribution of a drug if the Vd = 14 L?
A
Drug in the plasma & interstitial fluid (ECF)
3
Q
What is the distribution of a drug whose Vd = 40-45 L?
A
Drug occupies TBW
4
Q
What is the distribution of a drug with a Vd = > 45 L?
A
Widely distributed and bound in body tissues
5
Q
What is the Donnan effect?
A
Negative charge of proteins within the plasma of the ECF contributes to the presence of a higher amount of cations in comparison to the interstitial fluid of the ECF
6
Q
Pitting Edema is defined as?
A
Increased interstitial volume
7
Q
Non-pitting edema is defined as?
A
Swollen cells due to increased ICF volume
