Bo5 Flashcards
35 yr old gay man complains of a flickering light in the left eye. VA right 6/6, left 6/36 (amblyopia). Retinal examination shows red lesions extending from the periphery in a 'brush fire' pattern. What is the likely cause? a. CMV retinitis b. Retinal detachment c. Diabetic retinopathy
CMV retinitis
35 yr old gay man complains of a flickering light in the left eye. VA right 6/6, left 6/36 (amblyopia). Retinal examination shows red lesions extending from the periphery in a 'brush fire' pattern. What is the first line treatment? a oral valganciclovir b IV ganciclovir c iv cidofovir d iv foscarnet
Oral valganciclovir first line
35 yr old gay man complains of a flickering light in the left eye. VA right 6/6, left 6/36 (amblyopia). Retinal examination shows red lesions extending from the periphery in a ‘brush fire’ pattern. He has new diagnosis of HIV and is not on HAART.
What is the management plan?
a induction followed by maintenance oral valganciclovir and immediate start HAART
b induction followed by maintenance oral valganciclovir and start HAART after 30 days
c induction followed by maintenance oral valganciclovir, oral steroids and start HAART
???
valganciclovir + start HAART
Steroids only if immune reconstitute uveitis
Which ARVs will affect/interact with POP? a lopinavir b lamivudine c tenofovir d abacavir
???
lopinavir
What is the level of evidence for moxifloxacin for PID Rx?
a grade 1A
b grade 1B
c grade 2A
grade 1A
Review sensitivity/specificity/PPV/NPV
Discuss
HIV diagnoses in MSM in the UK are reducing. Which part of the country has seen the greatest decline? a London b Midlands and East England c North England d Scotland e Northern Ireland
London
https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/835084/hpr3119_hiv18-v2.pdf
HIV diagnosis in heterosexual people in the UK are declining. Which ethnic group is experiencing the greatest decline? a White b Black African c Black Caribean d Asian
Black African
https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/835084/hpr3119_hiv18-v2.pdf
Which exposure group is seeing the greatest decline in new HIV diagnoses since 2014? a gay/bisexual men b heterosexual women c heterosexual men d PWID
gay/bisexual
https://www.hiv-lens.org/visualisation/overview/country/england/
What is the difference between empirical and epidemiological treatment?
???
Discuss
A 26 yo woman presents with multiple painful friable vesicular lesions on her vulva. You suspect herpes simplex virus. Which test will confirm this for you? a swab for HSV DNA PCR b swab for HSV culture c serology for HSV-2 IgG d serology for HSV-1 & 2 IgG
swab for HSV DNA PCR
A 21 yo MSM is diagnosed with HIV and hepatitis B. His HBV DNA PCR is >2000. What is the recommended treatment of hepatitis B? a tenofovir + emtricitabine b entecavir + ART c lamivudine + dolutegravir d lamivudine + emtricitabine
Crap options... TDF/FTC or TDF/3TC as part of ART Never FTC or 3TC alone TDF can be alone entecavir only is fully suppressed HIV https://www.bhiva.org/file/TcrCoXjAGRaHb/HepatitisGuidelines2013.pdf
12 yr old girl with vaginal discharge tests positive for gonorrhoea. On examination she has intact hymen. She denies sexual contact. What is the likely explanation? a vertical transmission b fomite transmission c consensual sex d sexual abuse e false positive
???
False positive
or
Sexual abuse (BASHH guideline suggest this but no comment about relevance of hymen)
https://www.bashhguidelines.org/media/1081/2674.pdf
25 yo woman with TB. treatment includes rifampicin and isoniazid. She asks you for contraception. What is the best option for her? a COCP b CHC patch c Implant d DMPA e POP
DMPA
oral pills, patches, rings and SDI can all be reduced by enzyme inducers
IUS/IUD alternative contraception but not in Bo5
If you need a second test to confirm a positive test for chlamydia trachomatis - what do you need the second test to have? a high sensitivity b high specificity c high PPV d high NPV
???
Discuss
HIV positive patient with eGFR 40, what ARV can be given at normal dose? a abacavir b lamivudine c zidovudine d tenofovir disoproxil e emtricitabine
??? abacavir or zidovudine both ok until severe CKD or ESRF (emc and bnf)
A 23 yo woman has vaginal discharge and vulvitis, a high vaginal swab shows yeasts. What is the recommended treatment?
a clotrimazole pessary 500mg
b fluconazole 150mg oral
c clotrimazole 5% cream
fluconazole oral (if no contraindication)
A 23 yo woman presents with recurrent vaginal discharge and vulvitis. A high vaginal swab confirms candida. What is the most likely non-albicans candida?
a C. guilliermondii
b C. glabrata
c C. parapsilosis
C. glabrata
and
C. krusei most common non-albicans
A 23 yo woman presents with recurrent vaginal discharge and vulvitis. A high vaginal swab confirms Candida krusei. What is the recommended treatment?
a fluconazole 150mg orally once weekly for 6 months
b topical imidazole 14 days
c Nystatin pessaries 100,000units for 14 nights
Nystatin pessary first line for non-albicans or azale resistance
25 yo man presents with a swollen right scrotum. He thinks it has grown over the past month. There is no pain and he cannot recall any injury. On examination there is obvious right scrotal swelling which feels fluctuant. The testis is difficult to palpate. What is the likely diagnosis? a epididymitis b hydrocele c varicocele d epididymal cyst e inguinal hernia
Hydrocele
25 yo man presents with a swollen, painful right scrotum over the past week. He has no other symptoms. He last had sex 2/52 ago with his girlfriend. He has been with her for the past 2 months. On examination he has tender epididymus and right testicle. What is the best treatment?
a oral doxycycline 100mg BD 2 week
b IM ceftriaxone 1g and doxycycline 100mg BD 2 weeks
c IM ceftriaxone 1g and ofloxacin 200mg BD 10 days
cef + DOXY
29 yo man presents with a swollen, painful right scrotum over the past week. He has no other symptoms. He last had UIAI sex 2/52 ago with casual male partner. He has had 4 partners in the past 3 months, all UIAI. On examination he has tender epididymus and right testicle. What is the best treatment?
a oral doxycycline 100mg BD 2 week
b IM ceftriaxone 1g and doxycycline 100mg BD 2 weeks
c IM ceftriaxone 1g and ofloxacin 200mg BD 10 days
cef + OFLOXACIN
For acute epididymitis most likely caused by sexually-transmitted chlamydia and gonorrhoea and/or
enteric organisms (men who practice insertive anal sex)
25 yo man presents with a swollen right scrotum. He thinks it has grown over the past month. There is no pain and he cannot recall any injury. On examination there is obvious right scrotal swelling which feels fluctuant. The testis is difficult to palpate. What is the next most appropriate investigation? a NAAT for GC/CT b US testes c Urethral culture d No further investigation e AFP
US testes
- hydrocele in 20-40 yr old or unable to palpate teste needs exclusion malignancy
21 yo male presents with dysuria for 1 week and swelling and pain of right knee for past 4 days. He has had sex with female partners in past 3 months and has never used condoms. Microscopy shows PMNLs >5/5xhigh power field. You suspect SARA. What is the best treatment?
a doxycyline 100mg BD 1 week
b IM ceftriaxone 1g +doxycycline 100mg BD
c doxycycline 100mg BD 2 week
d azithromycin 2gram oral
e prednisolone 30mg daily
doxycycline 100mg BD 7 days
As per uncomplicated GU infection guideline
would also add NSAID and supportive care
25 yo woman who has sex with women attends the GUM clinic for a routine sexual health screen. She asks you about her risk of STIs. What is the most common STI in WSW? a chlamydia b gonorrhoea c HSV d syphilis e HIV
??? no idea - data lacking
HSV
or
chlamydia
Found another Q that suggests HPV…
25 yo woman who has only female sexual partners attends the GUM clinic with vaginal discharge. She has no vulval discomfort. What is the most common cause for the vaginal discharge? a gonorrhoea b mycoplasma c chlamydia d bacterial vaginosis e candida
Bacterial vaginosis