HIV misc

Question 1

Which study showed non-inferiority of dolutegravir+lamivudine vs TDF/FTC+DTG?

Answer 1

GEMINI

Question 2

Who should lamivudine/dolutegravir not be used for?

Answer 2

HepB positive OR

HepB non-immune (consensus)

Question 3

At what CD4 count should lamivudine/dolutegravir not be used as first therapy? Why?

Answer 3

<200

GEMINI - dual regimen underperformed vs 3 drug regimen

Question 4

At what viral load should lamivudine/dolutegravir not be used as first therapy? Why?

Answer 4

> 500 000 copies

Question 5

What class of ARV is Daravirine?

Answer 5

NNRTI

Question 6

What benefit does daravirine have?

Answer 6

improved lipid profile

Question 7

What proportion of babies born with HIV will survive beyond 2 years old WITHOUT ARV therapy?

Answer 7

50%

Question 8

What 2 trials supported early ARV treatment rather than deferred treatment?

Answer 8

START

TEMPRANO

Question 9

What level of adherence is required to ensure viral load remains undetectable?

Answer 9

90%

Question 10

What study was the first one to show if viral load undetectable it was untransmissable?

Answer 10

HPTN 052 (mainly heterosexual relationship)