Blood Vessels and Hemodynamics Flashcards

1
Q

what are the 5 main types of blood vessels/

A
  1. arteries
  2. arterioles
  3. capillaries
  4. venules
  5. veins
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2
Q

what do arteries do?

A

carry blood away from the heart

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3
Q

what are arterioles?

A

smaller arteries

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4
Q

what are capillaries and what do they do?

A

thin walled, and accomplosh exchange of substances between blood and body tissues

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5
Q

what are venules?

A

small veins where capillaries reunite

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6
Q

what do veins do?

A

convey blood from tissues back to heart

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7
Q

what are the 3 layers of blood vessel walls? describe

A
  1. tunica interna/intima: epithelial inner lining
  2. tunica media: smooth muscle and elastic connective tissue
  3. tunica externa/adventitia: connective tissue outer covering
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8
Q

what accounts for the 5 types of blood vessels

A

modifications to the basic three layers provide the structural and functional differences in the 5 types of blood vessels

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9
Q

what does the tunica interna form and what is it in direct contact with?

A

forms the inner lining of the blood vessel; in direct contact with blood

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10
Q

describe the tunica interna’s contribution to the thickness of vessel walls

A

minimal contribution to overall vessel wall thickness

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11
Q

what is the innermost layer of the tunica interna? what is it continuous with?

A

endothelium that is continuous with the endocardial lining of the heart

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12
Q

what is the endothelium that is the innermost layer of the tunica interna made of?

A

a thin layer of flattened cells that line the inner surface of the entire cardiovascular system

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13
Q

what does the endothelial layer of the tunica intima do?

A

facilitates efficient blood flow by reducing surface friction

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14
Q

what is the second component of the tunica intima?

A

the basement membrane

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15
Q

what are the 3 components of the tunica intima, from innermost to outermost?

A
  1. endothelium
  2. basement membrane
  3. internal elastic lamina
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16
Q

what does the basement membrane of the tunica intima provide? (3)

A
  1. provides physical support base for epithelial layer
  2. provides framework of collagen fibers that gives basement membrane significant tensile strength
  3. provides resilience for strength and recoil
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17
Q

what does the basement membrane of the tunica intima do? (2)

A
  1. anchors endothelium to underlying connective tissue
  2. regulates molecular movement
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18
Q

describe how the basement membrane of the tunica intima regulates molecular movement

A

appears to play an important role in guiding cell movement during tissue repair of blood vessel walls

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19
Q

what is the internal elastic lamina?

A

the outermost part of the tunica intima

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20
Q

what does the internal elastic lamina of the tunica intima form?

A

forms the boundary between tunica interna and tunica media

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21
Q

what does the internal elastic lamina of the tunica intima do and how?

A

facilitates diffusion of materials through tunica interna to tunica media via a thin sheet of elastic fibers with window-like openings

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22
Q

what is the tunica media?

A

a muscular and connective tissue layer

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23
Q

which of the 3 blood vessel layers varies most among the vessel types?

A

tunica media

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24
Q

describe the tunica media in most vessels (2)

A
  1. relatively thick layer
  2. mainly smooth muscle cells and sustantial amounts of elastic fibers
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25
Q

what is the primary role of the smooth muscle cells in the tunica media?

A

regulate diameter of the vessel

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26
Q

what stimulates the smooth muscle of the tunica media to contract and what does this result in?

A

increased sympathetic stimulation stimulates the smooth muscle of the tunica media to contract; resulting in vasoconstriction or narrowing of the vessel lumen

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27
Q

along with increasing vasoconstriction, what does sympathetic stimulation result in relating to the tunica media?

A

also results in vasodilation and release of nitric oxide and lactic acid

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28
Q

what regulates the rate of blood flow through different parts of the body?

A

the extent of smooth muscle contractions in walls of vessels

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29
Q

what is crucial in regulating blood pressure relating to the tunice media?

A

the extent of smooth muscle contraction in a particular vessel type

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30
Q

what happens with the tunica media if an artery is damaged?

A

smooth muscle contracts (vascular spasm) to limit blood loss

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31
Q

what is the most variable to the tunics?

A

tunica media

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32
Q

what is the external elastic lamina?

A

a network of elastic fibers that separates the tunica media from the tunica externa

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33
Q

what is the tunica externa? what is it made of? what does it contain?

A

the outer covering of a blood vessel, consists of elastic and collagen fiber; contains numerous nerves

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34
Q

what does the tunica externa do?

A

helps anchor vessels to surrounding tissue

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35
Q

what are the vasa vasorum? (3)

A
  1. small vessels that supply blood to tissues of larger vessels
  2. vessels to the vessels
  3. can be seen on large vessels including the aorta
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36
Q

describe the compliance of arteries

A

high; walls stretch/expand easily without tearing in response to small increases in pressure

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37
Q

describe the tunica media of arteries

A

thick muscular-to-elastic tunica media

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38
Q

what is the largest type of artery in the body?

A

elastic arteries

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39
Q

give 3 examples of elastic arteries

A
  1. aorta
  2. pulmonary trunk
  3. branches of aorta
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40
Q

describe the vessel walls of arteries

A

relatively thin (10% of total diameter) compared with overall size of vessel

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41
Q

describe the tunica media of arteries

A

thick tunica media, dominated by elastic fibers called elastic lamellae

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42
Q

what do elastic arteries do?

A

help propel blood downward while ventricles are relaxing

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43
Q

when blood is ejected from the heart into arteries, what happens to accodomate the surge of blood?

A

artery walls stretch

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44
Q

as elastic fibers stretch, what happens?

A

they momentarily store mechanical energy are a pressure reservoir

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45
Q

what happens to the thing elastic fibers of arteries as they stretch to serve in the function as a pressure reservoir?

A

they convert stored energy into kinetic energy of blood so that blood continues to move through arteries even while ventricles are relaxed

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46
Q

what are elastic arteries also called?

A

conducting arteries

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47
Q

what are the 2 types of arteries?

A
  1. elastic arteries
  2. muscular arteries
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48
Q

describe muscular arteries’ tunica media compared to elastic arteries

A

muscular artery tunica media contains more smooth muscle and fewer elastic fibers than elastic arteries

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49
Q

describe the walls of muscular arteries compared to elastic arteries

A

muscular arteries have much thicker walls than elastic arteries

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50
Q

describe the vasoconstriction/vasodialtion capabilities of muscular versus elastic arteries

A

muscular arteries are capable of greater vasoconstriction/vasodialtion than elastic arteries

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51
Q

describe the range of size associated with muscular arteries

A

femoral is pencil sized where some are string sized that enter organs

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52
Q

what are muscular arteries also called?

A

dsitributing arteries

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53
Q

what percentage of total vessel diameter do muscular artery walls comprise?

A

25%

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54
Q

do muscular arteries recoil like elastic arteries? what does this mean?

A

do not recoil like elastic arteries, so can’t propel blood

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55
Q

what is primarily responsible for the function of muscular arteries?

A

the thick, muscular tunica media

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56
Q

what is vascular tone?

A

the ability of muscle to contract and maintain state of partial contraction

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57
Q

what does the realtively thick walls of muscular arterioles allow for?

A

not as compliant, so can use vasodilation and vasoconstriction to shift blood to where it’s needed

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58
Q

what does vascular tone do in muscular arteries?

A

stiffens vessel walls and is important in maintaining vessel pressure and efficient blood flow

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59
Q

what are anastomoses?

A

unions of branches where 2 or more arteries supply the same body region

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60
Q

what do anastomoses do?

A

provide alternate routes for blood to reach tissue

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61
Q

what is collateral circulation?

A

alternate route of blood flow to body part

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62
Q

do end arteries anastomose?

A

nope

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63
Q

what does obstruction of an end artery result in?

A

necrosis of the tissue it serves

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64
Q

how might blood supply also be provided (other than anastomoses)?

A

alternative blood routes

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65
Q

what are arterioles?

A

small arteries

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66
Q

what do arterioles do?

A

regulate blood flow into capillary network

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67
Q

describe the wall thickness of arterioles

A

1/2 vessel diameter

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68
Q

describe the tunica interna and elastic lamina of arterioles

A

think tunica intima and thin fenestrated elastic lamina

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69
Q

what is the terminal end of arterioles called? what does it taper toward?

A

metarteriole, tapers toward capillary junction

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70
Q

where are precapillary sphincters located?

A

at metarteriole/capillary junctions

71
Q

what do precapillary sphincters do?

A

monitor blood flow into capillaries

72
Q

describe the nerves of arterioles

A

abundant unmyelinated sympathetic nerves

73
Q

what do the abundant unmyelinated sympathetic nerves of arterioles do?

A

can alter diameter and therefore rate of blood flow and resistant

74
Q

what is always needed to maintain blood pressure?

A

some vascular tone

75
Q

what does resistance mean in relation to arterioles?

A

opposition to blood flow

76
Q

what are arterioles also reffered to as?

A

resistance vessels

77
Q

what is the resistance of arterioles mainly due to?

A

friction between blood and inner walls of blood vessels

78
Q

how does the diameter of arterioles relate to their resistance?

A

the smaller diameter of arterioles provides greater friction and contributes to greater resistance

79
Q

what is contraction of smooth muscle in vessels called and what does this result in in arterioles?

A

vasocontriction, increases resistance and decreases blood flow into capillaries

80
Q

what are the smallest blood vessels?

A

capillaries

81
Q

what do capillaries connect?

A

connect arterial outflow to venous return

82
Q

about how many capillaries do we have in our bodies?

A

approx 20 billion

83
Q

what is microcirculation?

A

flow of blood from metarteriole through capillaries into post-capillary venule

84
Q

what is the primary function of capillaries and how is this accomplished?

A

primary function is exchange of substances between blood and intersititial fluid, accomplished through thin-walled exchange vessels

85
Q

describe the structure of capillaries and what that structure is important for

A

walls composed of a single layer of eptihelial cells and basement membrane; important for movement of substances into tissues

86
Q

where does exchange of nutrients occur? (2)

A
  1. through capillaries
  2. through beginning of venules
87
Q

when is the entire capillary network of a tissue active?

A

when the tissue is active

88
Q

what happens in the capillary network when metabolic needs are low?

A

blood flows through a small part of the capillary network only

89
Q

what is the capillary bed?

A

a network of 10-100 capillaries that arise from a single arteriole

90
Q

where do capillaries move nutrients?

A

to areas with the highest demand

91
Q

what are the 3 types of capillaries?

A
  1. continuous
  2. fenestrated
  3. sinusoid
92
Q

what is the most abundant type of capillary?

A

continuous capillaries

93
Q

describe continuous capillaries

A

a continuous tube interrupted only by intercellular clefts

94
Q

where are continuous capillaries located? (4)

A
  1. CNS
  2. lungs
  3. skin
  4. muscle
95
Q

what are intracellular clefts?

A

where exchange of nutrients occurs

96
Q

describe the cells of fenestrated capillaries

A

endothelial cells that have many fenestrations (small pores)

97
Q

where are fenestrated capillaries located? (2)

A
  1. kidneys
  2. villi of small intestines
98
Q

describe the structure and pattern of sinusoid capillaries

A

wider and more winding than other capillaries, with large fenestrations

99
Q

do sinusoid capillaries have a basement membranes?

A

nope

100
Q

describe the intracellular clefts of sinusoid capillaries

A

very large

101
Q

what do sinusoid capillaries allow for?

A

allow proteins (like blood cells) to pass from tissue to blood strem

102
Q

where are sinusoid capillaries found? (3)

A
  1. adrenal glands
  2. liver
  3. spleen
103
Q

what is a thoroughfare channel?

A

where blood can pass from metarterioles to veules without much flow through capillaries

104
Q

describe the walls of venules and what this means for shape maintenance

A

thin-walled and do not readily maintain their shape

105
Q

what do venules do?

A

drain capillary blood and begin return flow of blood to the heart

106
Q

what are the 2 types of venules?

A
  1. postcapillary venules
  2. muscular venules
107
Q

what do the postcapillary venules do? (2)

A
  1. initially receive blood from capillaries
  2. are a significant site of exchange of nutrient and wastes
108
Q

describe postcapillary venules

A

very porous

109
Q

what do postcapillary venules form since they are a significant site of exchange of wastes and nutrients?

A

form part of microcirculatory exchange unit

110
Q

describe the walls of muscular venules and what this means?

A

thicker walls means no exchanges with interstitial fluid

111
Q

describe the smooth muscle layers of muscular venules (compare to arteries)

A

1-2 layers of circular smooth muscle

112
Q

what is the most distensible element of the vascular system? what do they do?

A

the thin walls of venules; expand and serve as reservoirs for large volumes of blood

113
Q

describe the walls of veins relative to their total diameter

A

very thin walled, less than 1/10 of total vessel diameter

114
Q

compare the tunica intima of veins to arteries

A

tunica intima of veins is thinner than arteries

115
Q

compare the tunica media of veins to arteries including descriptions of smooth muscle and elastic fibers

A

tunica media of veins is much thinner than arteries, with relatively little smooth muscle and elastic fibers

116
Q

describe the tunica externa of veins and what it includes (2)

A

tunica externa is the thickest layer of veins; includes collagen and elastic fibers

117
Q

do veins contain the elastic lamina found in arteries?

A

no; veins lack the elastic lamina found in arteries

118
Q

how distensible are veins and what is their limit?

A

veins are distensible enough to adapt to variations in volume and blood pressure passing through them but not designed to withstand high blood pressure

119
Q

compare and contrast veins to arteries (4)

A
  1. vein lumen is larger than compaarable arteries
  2. blood pressure in veins is considerably lower than in arteries
  3. veins contain valves; arteries do not
  4. veins are more numerous than arteries
120
Q

how is blood flow from a cut vein different than blood flow from a cut artery?

A

when you cut an artery, the blood flow will be bright and pulsing from the high pressure; when you cut a vein, the blood flow will be darker and not pulsing due to low blood pressure

121
Q

describe the valves of veins (4)

A
  1. thin folds of tunica interna
  2. forms flap-like cusps
  3. project into lumen pointing toward the heart
  4. aid in venous return by preventing backflow of blood
122
Q

what are varicose veins?

A

when veins become dilated and twisted in appearance due to leaky venous valves

123
Q

where are varicose veins most common? (3) which is the most serious location?

A
  1. esophagus- most dangerous
  2. anal canal
  3. superficial veins of legs
124
Q

what is another name for varicose veins?

A

varices

125
Q

what causes esophageal varices? what are the symptoms? (2)

A

when the portal vein is backed up due to scar tissue in the liver and interferes with veinous flow; symptoms are vomiting blood and black stool

126
Q

what are anal canal varices also known as?

A

hemorrhoids!

127
Q

what are the 2 causes of varicose veins?

A
  1. congenital
  2. mechanical stress
128
Q

what happens with varicose veins due to the leaky valves?

A

leaking valves may allow backflow of blood from deep veins to less efficient superficial veins causing blood pools

129
Q

what is DVT?

A

deep vein thrombosis; a clot in the veins that blocks blood flow or could travel to lungs or brain = bad news bears

130
Q

what do varicose veins to do surrounding veins and tissue?

A

create pressure that distends the veins and allows fluid to leak into surrounding tissue

131
Q

describe the affected vein and surrounding tissue of varicose veins

A

inflamed and tender

132
Q

what type of veins are more susceptible to varicose veins? which are less suscetpible and what?

A

superficial veins like the saphenous vein are more susceptible, while deep veins are less susceptible because they are supported by skeletal muscle

133
Q

list and describe 4 treatments for varicose veins

A
  1. elastic stockings (compression socks)
  2. sclerotherapy: inject tissue with compound to induce necrosis
  3. laser occlusion: shut down a section of the vein
  4. stripping: removing part of the vein
134
Q

describe blood distrubution at rest (but rly just know the first one)

A
  1. 64% in veins and venules
  2. 13% in systemic arteries and arterioles
  3. 7% in systemic capillaries
  4. 9% in pulmonary blood vessels
  5. 7% in the heart
135
Q

what serves are the blood reservoir of the body? what can it do with this reservoir?

A

the systemic venous system; can divert blood when needed

136
Q

what happens involving blood distribution during exercise?

A

the cardiovascular center in the medulla oblongata sends sympathetic impulses to veins causing venoconstriction and allowing greater blood flow to muscles

137
Q

what happens to blood volume and pressure during hemorrhage?

A

blood volume and pressure decrease

138
Q

what happens to counteract the drop in blood pressure during hemorrhage?

A

venoconstriction

139
Q

what are principle blood reservoirs?

A

veins in abdominal organs (like the liver and the spleen) and the skin

140
Q

what is bulk flow?

A

a passive process where large numbers of ions, molecules, or aprticles in fluid move together in the same direction

141
Q

how is bulk flow different from diffusion?

A

bulk flow movement occurs at a much faster rate than can be accounted for by diffusion alone

142
Q

where and when does bulk flow occur?

A

from areas of higher pressure to areas of lower pressure as long as a pressure difference exists

143
Q

what is bulk flow more important for than diffusion?

A

bulk flow is more important for regulation of relative volumes of blood and interstitial fluid

144
Q

what is diffusion more inportant for than bulk flow?

A

diffusion is more important for solute exchange between blood and interstitial fluid

145
Q

what is filtration?

A

the pressure-driven movement of fluid/solutes from blood capillaries into interstitial fluid

146
Q

what is reabsorption?

A

pressure-driven movement from interstitial fluid into capillaries

147
Q

what 2 pressures promote filtration?

A
  1. blood hydrostatic pressure (BHP)
  2. interstitial fluid osmotic pressure (IFOP)
148
Q

what 2 pressures promote reabsorption?

A
  1. blood colloud pressure (BCOP)
  2. interstitial fluid hydrostatic pressure (IFHP)
149
Q

what is hydrostatic pressure?

A

pressure from water component of fluid

150
Q

what is osmotic pressure?

A

pressure from water moving to where solutes (proteins) are

151
Q

what is net filtration pressure? what does it determine?

A

balance of pressures that are constantly opposing each other in capillaries; determines whether volumes of blood and intersitital fluid change

152
Q

what is Starling’s law of the capillaries?

A

normally, the volume of fluid and solutes reabsorbed is almost as large as volume filtered

153
Q

what is BHP? describe

A

blood hydrostatic pressure due to the pressure that the water in blood plasma exerts against blood vessel walls

154
Q

what does BHP do?

A

pushes fluid out of capillary into interstitial fluid

155
Q

give values for BHP at arterial and venous ends of capillaries

A

arterial: 35 mmHg
venous: 16 mmHg

156
Q

what is IHP? describe

A

interstitial hydrostatic pressure; opposing pressure of interstitial fluid

157
Q

what does IHP do?

A

pushes fluid from interstitial spaces back into capillaries

158
Q

describe IHP contribution to net filtration pressure

A

close to 0; minimal contribution

159
Q

what is the difference in pressure across capillary walls due to?

A

presence of plasma proteins in blood that are too large to move through fenestrations or gaps between endothelial cells

160
Q

what is BCOP? describe

A

blood colloid osmotic pressure; the force caused by suspension of large proteins in plasma

161
Q

what does BCOP do?

A

pulls fluid from interstitial spaces into capillaries

162
Q

what is the average BCOP in most capillaries?

A

26 mmHg

163
Q

what is IFOP? describe

A

intersitial fluid osmotic pressure; opposes BCOP

164
Q

what does IFOP do?

A

pulls fluid out of capillaries

165
Q

describe the level of IFOP/contribution to net filtration pressure and why

A

very small; only tine amounts of protein in interstitial fluid

166
Q

what determines if fluid leaves or enters capillaries?

A

balance of pressures

167
Q

when does filtration occur in capillaries?

A

in pressures pushing fluid out of capillaries exceed those pulling fluids in

168
Q

when does reabsorption occur in capillaries?

A

if pressures pushing fluid out of interstitial space into capillaries exceeds those that pull fluids out of capillaries

169
Q

what is the equation to find net filtration pressure (NFP)?

A

NFP = (BHP + IFOP) - (BCOP+IFHP), or pressures promoting filtration minue pressures promoting reabsorption

170
Q

what is the average NFP aat the arterial end of capillaries and what does this mean?

A

avg is 10 mmHg; so net outward pressure, fluid moves out of capillary

171
Q

what is the average NFP at venous end of capillaries; what does this mean?

A

avergae is -9 mmHg, so net inward pressure and fluid moves into capillary from interstitial spaces

172
Q

on average, what percentage of blood filtered out of capillaries is reabsorbed?

A

85%

173
Q

how much blood is filtered daily? how much of that is reabsorbed and where does the rest go?

A

20L filtered daily; 17L reabsorbed and 3L enter lymphatic capillaries

174
Q

a person who has liver failure can’t synthesize a normal amount of plasma proteins. How does a deficit of plasma proteins affect blood colloid osmotic pressure and what is the effect on capillary exchange?

A

there will be less reabsorption because fewer plasma proteins decreases BCOP; the buildup of fluid in the tissue can lead to edema