Blood Disorders (Exam III) Marcus's Cards Flashcards
What are the S/S of vWF disorder?
Easy bruising
epistaxis
menorrhagia
What would lab values be for someone with vWF deficiency?
- Normal PT & aPTT
- Bleeding time is prolonged
What are the treatments for vWF deficiency?
- Desmopressin
- Cryoprecipitate
- Factor VIII
How does DDAVP work in regards to treatment of von Willebrand deficiency??
Stimulates vWF release from endothelial cells
What is the dose for DDAVP?
0.3 mcg/kg in 50 mL over 15-20 mins (Do not bolus)
What is the onset & duration of DDAVP?
- Onset: 30mins
- Duration: 6-8hrs
What are side effects of DDAVP?
- HA
- rubor
- hypotension
- tachycardia
- hyponatremia
- water intoxication (excessive water retention)
What is the most major side effect of DDAVP?
Hyponatremia
Someone that gets DDAVP needs to be on what?
Fluid restriction 4-6hrs before & after DDAVP
What blood product can be utilized for vWF disease if the patient is unresponsive to DDAVP?
Cryoprecipitate
- 1 unite increases fibrinogen by 50mg/dL
1 unit of Cryo raises the ____ level by ___?
Fibrinogen by 50 mg/dL
What is a potential risk factor with cryoprecipitate?
Increased risk of infection (not submitted to viral attenuation)
What is Factor VIII concentrate made of?
Pool of plasma from a large number of donors.
When is Factor VIII given?
- give to in vWF disease if unresponsive to DDAVP (type 3! Maybe type 2B & 2N)
- Preop and intraop
- contains F VIII & vWF
When should DDAVP be given prior to surgery?
60mins before Sx
On set of DDAVP is 30 min. It needs to be infused over 15 to 20 minutes