Blood Coagulation

Question 1

Heparin: Action

Answer 1

Inactivated clotting factors inhibiting prothrombin and thrombin conversion

Question 2

Heparin: A/E

Answer 2

Heparin get induced thrombocytopenia (HIT) - decreased platelets, life threatening, HIT antibodies

Hemorrhage

Question 3

Heparin Antidote

Answer 3

Protamin sulfate

Question 4

Heparin: aPTT values normal and therapeutic

Answer 4

Normal 25-35 sec
Therapeutic 45-70

Taken one hour before dose given or whenever for IV admin

Question 5

Heparin: Class

Answer 5

Anticoagulation

Question 6

Warfarin (Coumadin): Class

Answer 6

Vitamin K anti antagonist / anticoagulant

Question 7

Warfarin (Coumadin): Used for

Answer 7

Preventing DVT and from clots getting bigger
Long term venous thromboembolic disorders
Given the after MI to decrease stroke, reinfraction and death

Question 8

Warfarin (Coumadin): Antidote

Answer 8

Vitamin K given when INR is over 5

Question 9

Warfarin (Coumadin): Action

Answer 9

Prevents clotting factors in the liver

Doesn’t effect clotting of platelet function until 3-5 days

Question 10

Warfarin (Coumadin): INR

Answer 10

2.5-3.5

Question 11

Warfarin (Coumadin): A/E

Answer 11

Bleeding: IV site, brushing, gums, stool and urine

Question 12

Heparin: Rx

Answer 12

Prevent DVT and PE