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Boards > Blood Clotting > Flashcards

Blood Clotting Flashcards

1
Q

3 phases to formation of clot

A
  1. Vascular phase: blood vessels constrict at site of injury
  2. Platelet plug formation, release of factors that aid in vasoconstriction
  3. Clotting factors and cascades
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2
Q

What initiates the intrinsic pathway?

A

Contact with foreign surface

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3
Q

What initiates the extrinsic pathway?

A

Tissue injury

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4
Q

What dissolves clots in the intrinsic path?

A

Factor XIIa splits plasminogen to plasmin

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5
Q

What dissolves clot in the extrinsic pathway?

A

Tissue plasminogen activators split plasminogen to plasmin

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6
Q

What are fibrin clots dissolved into?

A

Fibrin degradation products
-these dissolve into D and E products which are removed from the reticulo-endothelial system and are found in the liver as Kupffers cells

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7
Q

Vitamin K provides a negative charge on which clotting factors, I order to attract the positive charge of calcium?

A

Factors II, VII, IX, and X

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8
Q

Factor I

A

Fibrinogen

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9
Q

Factor II

A

Prothrombin

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10
Q

Factor III

A

Thromboplastin

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11
Q

Factor IV

A

Calcium

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12
Q

Factor V

A

Proaccelerin

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13
Q

Factor VII

A

Proconvertin

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14
Q

Factor VIII

A

Antihemophilic

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15
Q

Factor IX

A

Plasma thromboplastin

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16
Q

Factor X

A

Stuart factor

17
Q

Factor XI

A

Plasma thromboplastin antecedent

18
Q

Factor XII

A

Hageman factor

19
Q

Factor XIII

A

Fibrin stabilizing factor

20
Q

Factors used in intrinsic pathway

A

Factor XII, factor XI, factor IX, factor VIII, factor IV

21
Q

Factors used In extrinsic pathway

A

Factor III, factor VII, factor IV

22
Q

Factors used in common pathway

A

X, V, II,I,XIII! IV

23
Q

Injury or foreign surface contact

A
  1. Platelets aggregate and break down
  2. Prothrombin, thromboplastin, calcium
  3. Thrombin, fibrinogen
  4. Fibrin, RBCs become emeshed
24
Q

What factor initiates the intrinsic pathway?

A

Collagen

25
Q

What factor initiated the extrinsic pathway?

A

Tissue factor

26
Q

What factors begins the common pathway?

A

Factor X

27
Q

Final enzyme of coagulation system

A

Thrombin

28
Q

Tests for primary hemostasis

A

Platelet count

Bleeding time

29
Q

Tests for secondary hemostasis

A

PT: extrinsic and common pathway (normal is 11-13.4 sec)
PTT: intrinsic and common pathway (normal is 22-37 sec)

30
Q

Clot lying drugs

A

Must be used within 3 hours of clot formation

Recombinant tPA, streptokinase, urokinase

Boards (9 decks)

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