Blood Clotting Flashcards
3 phases to formation of clot
- Vascular phase: blood vessels constrict at site of injury
- Platelet plug formation, release of factors that aid in vasoconstriction
- Clotting factors and cascades
What initiates the intrinsic pathway?
Contact with foreign surface
What initiates the extrinsic pathway?
Tissue injury
What dissolves clots in the intrinsic path?
Factor XIIa splits plasminogen to plasmin
What dissolves clot in the extrinsic pathway?
Tissue plasminogen activators split plasminogen to plasmin
What are fibrin clots dissolved into?
Fibrin degradation products
-these dissolve into D and E products which are removed from the reticulo-endothelial system and are found in the liver as Kupffers cells
Vitamin K provides a negative charge on which clotting factors, I order to attract the positive charge of calcium?
Factors II, VII, IX, and X
Factor I
Fibrinogen
Factor II
Prothrombin
Factor III
Thromboplastin
Factor IV
Calcium
Factor V
Proaccelerin
Factor VII
Proconvertin
Factor VIII
Antihemophilic
Factor IX
Plasma thromboplastin
Factor X
Stuart factor
Factor XI
Plasma thromboplastin antecedent
Factor XII
Hageman factor
Factor XIII
Fibrin stabilizing factor
Factors used in intrinsic pathway
Factor XII, factor XI, factor IX, factor VIII, factor IV
Factors used In extrinsic pathway
Factor III, factor VII, factor IV
Factors used in common pathway
X, V, II,I,XIII! IV
Injury or foreign surface contact
- Platelets aggregate and break down
- Prothrombin, thromboplastin, calcium
- Thrombin, fibrinogen
- Fibrin, RBCs become emeshed
What factor initiates the intrinsic pathway?
Collagen
