Blood and Tissue Protozoan Infections

Question 1

Disease caused by Toxoplasma gondii

Answer 1

Toxoplasmosis

Question 2

Host of Toxoplasma gondii

Answer 2

Cats ✰

Question 3

Mode of Transmission of t. gondii

Answer 3

Ingestion of sporulated oocyst from Cat feces
Ingestion of meat infected with trophozoite

Question 4

Diagnosis used in detection of toxopolasma

Answer 4

✰
Indirect fluorescent antibody test (FAT)
Enzyme immunoassay (ELISA)

Specific IgG, A, M, E

Question 5

Treatment of Toxoplasmosis

Answer 5

Sulfadizine + Pyrimethanine ✰
Alternative: CLindamycin

Question 6

S/S of Taxoplasmosis in Pregnant patient

Answer 6

Congenital infection
Still births
Severe brain damage
Vision problems

Question 7

Causes malaria

Answer 7

Plasmodium spp.✰

Question 8

Malaria

Answer 8

Ague
Intermitten Fever
Marsh fever
The Fever

Question 9

Vector of Plasmodium spp

Answer 9

Female Anopheles Mosquito

Question 10

Incubation period for Malaria

Answer 10

9-30 Days

Question 11

Disease caused by P. vivax

Answer 11

Benign Tertian Malaria

Question 12

Disease caused by P. ovale

Answer 12

Tertian Malaria

Question 13

Disease caused by P. malariae

Answer 13

Quartan malaria

Question 14

Disease caused by P. falciparum

Answer 14

Malignant tertian Malaria

Question 15

Most severe plasmodium spp.

Answer 15

Plasmodium falciparum

Question 16

Blood smear in Plasmodium vivax

Answer 16

Schuffner Dots/Ring

Question 17

Blood smear in Plasmodium ovale

Answer 17

James’ dots (Oval)
Enlarged RBC

Question 18

Blood smear in Plasmodium malariae

Answer 18

Ziemann’s Stippling

Question 19

Blood smear in Plasmodium falciparum

Answer 19

Maurer’s cleft
Banana-shaped

Question 20

Plasmodium spp. that infects young RBCs

Answer 20

P. vivax
P. ovale

Question 21

Plasmodium spp. that infects old RBCs

Answer 21

P. malariae

Question 22

Plasmodium spp. that infects both old and young RBCs

Answer 22

P. falciparum

Question 23

RBC lysis of P. vivax and P. ovale

Answer 23

After 48 hours

Question 24

RBC lysis of P. ovale

Answer 24

After 72 hours

Question 25

RBC lysis of P. falciparum

Answer 25

irregular burst After 36 - 48 hours

Question 26

Reproduction of Plasmodium in Human

Answer 26

Asexual - Schizogony Produces merozoites

Question 27

Reproduction of Plasmodium in anopheles Mosquito

Answer 27

Sexual - Sporogony Produces sporozoites (infective stage)

Question 28

Liver Schizogony

Answer 28

Exoerythrocyctic Schizogony

Question 29

RBC Schizogony

Answer 29

Erythrocytic Schizogony

Question 30

Dormant forms in the liver which can grow years later causing relapsing malaria

Answer 30

Hypnozoites - Produced by P. ovale and P. vivax

Question 31

Food source of Plasmodium

Answer 31

Hemoglobin

Question 32

Product of breakdown of Hemoglobin ingested by Plasmodium spp

Answer 32

Heme, Globin Hemozoin

Question 33

MOA of Quinine against Plasmodium spp.

Answer 33

inhibits nucleic acid synthesis, protein synthesis, and glycolysis and binds with hemazoin in parasitized erythrocytes

Question 34

Old DOC for uncomplicated malaria P. falciparum

Answer 34

Chloroquinine

Question 35

Old DOC for chloroquine-resistant

Answer 35

Artemether-Lumefantrine Atovaquone-Proguanil

Question 36

Old DOC for Blood stage of P. vivax and ovale

Answer 36

Chloroquine

Question 37

Old DOC for Liver stage P. vivax and ovale

Answer 37

Primaquine - Radical cure

Question 38

First line for confirmed, uncomplicated, and sever P. falciparum

Answer 38

Artemether-Lumefantrine

Question 39

2nd Line treatment for P. falciparum

Answer 39

Quinine + Clindamycin, tetracycline, Doxycycline

Question 40

Tx for unconcious patient with servere malaria

Answer 40

Artesunate supp.

Question 41

Treatment for all Plasmodium spp and mixed infections

Answer 41

Artemether - Lumefantrine