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Microbiology > Blood and Tissue Protozoan Infections > Flashcards

Blood and Tissue Protozoan Infections Flashcards

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Biology 101 flashcards
1
Q

Disease caused by Toxoplasma gondii

A

Toxoplasmosis

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2
Q

Host of Toxoplasma gondii

A

Cats ✰

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3
Q

Mode of Transmission of t. gondii

A

Ingestion of sporulated oocyst from Cat feces
Ingestion of meat infected with trophozoite

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4
Q

Diagnosis used in detection of toxopolasma

A

✰
Indirect fluorescent antibody test (FAT)
Enzyme immunoassay (ELISA)

Specific IgG, A, M, E

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5
Q

Treatment of Toxoplasmosis

A

Sulfadizine + Pyrimethanine ✰
Alternative: CLindamycin

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6
Q

S/S of Taxoplasmosis in Pregnant patient

A

Congenital infection
Still births
Severe brain damage
Vision problems

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7
Q

Causes malaria

A

Plasmodium spp.✰

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8
Q

Malaria

A

Ague
Intermitten Fever
Marsh fever
The Fever

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9
Q

Vector of Plasmodium spp

A

Female Anopheles Mosquito

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10
Q

Incubation period for Malaria

A

9-30 Days

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11
Q

Disease caused by P. vivax

A

Benign Tertian Malaria

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12
Q

Disease caused by P. ovale

A

Tertian Malaria

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13
Q

Disease caused by P. malariae

A

Quartan malaria

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14
Q

Disease caused by P. falciparum

A

Malignant tertian Malaria

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15
Q

Most severe plasmodium spp.

A

Plasmodium falciparum

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16
Q

Blood smear in Plasmodium vivax

A

Schuffner Dots/Ring

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17
Q

Blood smear in Plasmodium ovale

A

James’ dots (Oval)
Enlarged RBC

18
Q

Blood smear in Plasmodium malariae

A

Ziemann’s Stippling

19
Q

Blood smear in Plasmodium falciparum

A

Maurer’s cleft
Banana-shaped

20
Q

Plasmodium spp. that infects young RBCs

A

P. vivax
P. ovale

21
Q

Plasmodium spp. that infects old RBCs

A

P. malariae

22
Q

Plasmodium spp. that infects both old and young RBCs

A

P. falciparum

23
Q

RBC lysis of P. vivax and P. ovale

A

After 48 hours

24
Q

RBC lysis of P. ovale

A

After 72 hours

25
Q

RBC lysis of P. falciparum

A

irregular burst
After 36 - 48 hours

26
Q

Reproduction of Plasmodium in Human

A

Asexual - Schizogony
Produces merozoites

27
Q

Reproduction of Plasmodium in anopheles Mosquito

A

Sexual - Sporogony
Produces sporozoites
(infective stage)

28
Q

Liver Schizogony

A

Exoerythrocyctic Schizogony

29
Q

RBC Schizogony

A

Erythrocytic Schizogony

30
Q

Dormant forms in the liver which can grow years later causing relapsing malaria

A

Hypnozoites - Produced by P. ovale and P. vivax

31
Q

Food source of Plasmodium

A

Hemoglobin

32
Q

Product of breakdown of Hemoglobin ingested by Plasmodium spp

A

Heme, Globin
Hemozoin

33
Q

MOA of Quinine against Plasmodium spp.

A

inhibits nucleic acid synthesis, protein synthesis, and glycolysis and binds with hemazoin in parasitized erythrocytes

34
Q

Old DOC for uncomplicated malaria P. falciparum

A

Chloroquinine

35
Q

Old DOC for chloroquine-resistant

A

Artemether-Lumefantrine
Atovaquone-Proguanil

36
Q

Old DOC for Blood stage of P. vivax and ovale

A

Chloroquine

37
Q

Old DOC for Liver stage P. vivax and ovale

A

Primaquine - Radical cure

38
Q

First line for confirmed, uncomplicated, and sever P. falciparum

A

Artemether-Lumefantrine

39
Q

2nd Line treatment for P. falciparum

A

Quinine + Clindamycin, tetracycline, Doxycycline

40
Q

Tx for unconcious patient with servere malaria

A

Artesunate supp.

41
Q

Treatment for all Plasmodium spp and mixed infections

A

Artemether - Lumefantrine

Microbiology (17 decks)

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