Blood and Renal Flashcards
Name 2 Gp IIb/III antagonists
Tirofiban, Eptifibatide, Abciximab
Mechanism of action of aspirin as antiplatelet drug is it’s inhibitory action on
COX1
Clopdogren is an antiplatelet agent that acts by
Irreversibly blocking P2Y12 receptors on the surface of platelet
LMW heparin is preferred over unfractionated heparin because..
Less frequent thrombocytopenia, less haemorrhage complications
Apixaban is a
Direct inhibitor of Xa
Recent oral direct thrombin inhibitor used for stroke
Dabigatron
What to do in Heparin induced Thrombocytopenia
Stop heparin, Lep Fonda Arg for 30 days
Drug used in heparin OD
Protamine
Orally acting direct thrombin inhibitor
Dabigatron
The anticoagulant of choice in pregnancy
Heparin
LMW heparin acts on
Xa only
Thrombolytics can provide relative mortality reduction in the treatment of acute MI, if patient comes within..
7 - 12 hours
Thiazides act on … region of the nephron
DCT
Absolute CI for thrombolytics
Intracranial haemorrhage, Intracranial tumour
Relative CI to thrombolytic therapy is
Uncontrolled Hypertension
Furosemide acts on which region of nephron
PCT and DCT
Name some Potassium sparring diuretics
Spironolactone, Amiloride, Triamterene
Aldosterone antagonists are useful in the treatment of
CHF and Hypertension
Aldosterone action is on which region
CD
Thiazide diuretics ADR
Hypokalemia, Hyponatremia, Hypocalcemia, Hyperuricemia, acute saline depletion, Mg depletion, CNS disturbances
Spironolactone is CI with enalapril because it causes
Hyperkalemia
Loop diuretics such as furosemide act by
Inhibiting Na K 2Cl cotransport pump
Treatment of choice of SIADH
DOC for central diabetes insipidus
Desmopressin
