Anti Cancer and Misscelaneous

Question 1

… is the drug of choice for choriocarcinoma

Answer 1

Methotrexate

Question 2

A 56 y/o female presented with breast carcinoma and she was treated with TRASTUZUMAB. What is the MoA?

Answer 2

EGFR (epidermal growth factor receptor) antagonist

Question 3

… in the iron chelating agent which is infused before Doxurubicin therapy to reduce toxicity

Answer 3

Dexrazosane

Question 4

… is a microtubule damaging agent that act by enhancing polymerization of tubules

Answer 4

Paclitaxil

(vinca alkaloids inhibit formation of microtubule)

Question 5

Mercaptopurine is substrate for

Question 6

The anti cancer drug producing disulfiram like reaction is

Answer 6

Procarbazine

Question 7

… is a cell cycle specific anticancer drug which especially blocks G1 phase

Answer 7

Etoposide

Question 8

Anticancer drug useful in tracheal stenosis is …

Answer 8

Dexamethasone

Question 9

A 58 y/o female diagnosed with cancer was started on chemotherapy. Concominantly she was given mercaptoethanesulfonate to decrease the risk of hematuria. Which drug could be in her chemotherapy regimen.

Answer 9

MESNA for Hemorrhagic cystitis

Question 10

Anti cancer drug causing SIADH

Answer 10

Thalidomide, Vincristine

Question 11

… is given along with cyclophosphamide to prevent Hemorrhagic cystitis

Answer 11

Mesna

Question 12

The anthracycline antibiotic used for antitumour activity which has cardiotoxicity as a unique adr

Answer 12

Doxorubicin

Question 13

BCR ABL tyrosine kinase inhibitor used for treatment of CML

Answer 13

Imatinib

Question 14

The antineoplastic action of this drug is related to its high affinity for dihydrofolate reductase

Answer 14

Methotrexate

Question 15

This drug inhibits tubulin and inhibits formation of the mitotic spindle

Answer 15

Vinblastin

Question 16

Most emetogenic anti cancer drug causing pulmonary fibrosis

Answer 16

Nitroureas, Bleomycin

Question 17

Ondansetron inhibits which receptor

Answer 17

5HT3 receptor

Question 18

Which immunosuppressive drug requires monitoring of renal function regularly …

Answer 18

Cyclosporine A

Question 19

Which anti neoplastic drug is cell cycle specific and acts on S phase

Answer 19

Methotrexate

Question 20

Sickle cell anemia drug

Answer 20

Hydroxyurea

Question 21

DOC for CML

Answer 21

Imatinib

Question 22

Folate antagonists useful in cancer chemotherapy

Answer 22

Pemetrexed

Question 23

Cisplatin induced vomiting delayed type is treated by

Answer 23

Aprepitant

Question 24

Abiraterone acetate is a

Answer 24

Anti androgen

Question 25

Folinic acid counteracts the toxicity of

Answer 25

Methotrexate

Question 26

An example of epipodophyllotoxin

Answer 26

Etoposide