Blood and Immune Lecture 18 Flashcards
White Blood Cells are made up of
Neutrophils, Lymphocytes, Monocytes, Eosinophils and Basophils
Where do WBCs form
hemopoietic stem cells
WBCs can divide becuase
they contian DNA, nucleus and internal organs meaning they are fully differentiated and can perform a range of functions
WBCs are divided into cell types with or without _____
Cytoplasmic granules
Monocytes are produced in the _____ and circulate in the blood for - days before migrating through the ______ into tissue and develop into _____
Red Bone Marrow, 5-8, capillary walls, Macrophages
The function of neutrophils is
to enter the infection site and destroy bacteria (then die)
Monocytes enter tissue and…..
Mature into macrophages
destroy infecting material by phagocytosis and report the infection to the centralised “immune memory” system
What does the “immune memory” system do
Produces molecular tags which mark more difficult to recognise infections so macrophages can destroy them
What are MHC Class 2 molecules and where do they migrate to
display poeces of internlised proteins bound on surface molecules; Lymph Nodes
What cell are able to read the MHC Class 2 molecules
T Cells
What percentage of the circulating leukocytes do lymphocytes consist of
about 25% however, there are the majority of lymphocytes located in lymph nodes
What is complement attack
Bacteria tagged with Ig can be destroyed by plasma molecules collectively called the complement system.
Functions of Lymphocytes
- Immune recognition
- process and store info about possible infection
- T Memory - respond rapidly to cell infection
The Function of B Cells
- encode surface receptor for a particular antigen
- B Cells multiply and transform into plasma cells
- Make specific antibody for antigen
T Cells express…
Antigen specific T Cell receptor molecules
