Blood and Immune Lecture 17

Question 1

Why cannot red blood cells divide

Answer 1

No nucleus, DNA or organelles

Question 2

Where do red blood cells originate from

Answer 2

Reticulocyte cells - myeloid stem

Question 3

RBC life span

Answer 3

120 days

Question 4

What causes the red colour of RBCs

Answer 4

Iron in haem group

Question 5

How is the 3D structure of a protein determined

Answer 5

Crystallography

Question 6

What is the average diameter of a red blood cell

Answer 6

8 Micrometres

Question 7

What is carried on the red blood cell surface

Answer 7

Blood group antigens

Question 8

Haemoglobin is a(n) ________ protein containing four iron -containing haem groups

Answer 8

Alpha helical

Question 9

Haemoglobin is present at a concentration of ____ and in erythrocytes the concentration is ____ in the red blood cell

Answer 9

150mg/mL (15%) and 340mg/mL (34%)

Question 10

What is the structural protein of the RBCs which plays a role in the connective tissue

Answer 10

Collagen

Question 11

What is the concentration of serum albumin in blood

Answer 11

35 mg/mL

Question 12

What are the insoluble smaller molecules (lipid soluble) that are carried by serum albumin

Answer 12

steroids, lipids, hormones and man made drugs

Question 13

The protein chain in serum albumin is a(n) ____ made up of ___ amino acids

Answer 13

alpha helix; 585

Question 14

Concentration of immunoglobulin in blood serum

Answer 14

20 mg/mL

Question 15

What is the predominant class of immunoglobulin module found in the blood and how many domains does it have

Answer 15

IgG with 12 domains

Question 16

IgG is made up of mainly ____ and no ____

Answer 16

beta strands; alpha helices

Question 17

Antibody molecules are made up of WBCs called

Answer 17

B lymphocytes/B cells

Question 18

B Cells make immunoglobulins of the same antigen binding specificity and also…

Answer 18

a membrane bound version with the same specificity which remains attached to the B Cell

Question 19

Approx how many haemoglobin molecules in a RBC?

Answer 19

280 million

Question 20

Why do males have higher hematocrit it levels?

Answer 20

Increased testosterone in males increases EPO production so there is more RBC production.

Question 21

Length of haemoglobin?

Length of a and b strands?

Answer 21

40 Anstrom
A strand= 141aa
B strand= 146aa

Question 22

What is lysozyme?

Answer 22

129aa chain,

Antibacterial protein in tears