Blockings of tumors

Question 1

Germline mutation

Answer 1

Mutant rb allele is transmitted to offspring,

Bilateral

Question 2

Somatic mutation

Answer 2

Mutant rb allele occurs in somatic cell division
1 -> 2 mutant rb gene copies,
Unilateral

Question 3

What is diff of unilateral and bilateral in the Retinoblastoma gene mutation?

Answer 3

Bilateral - there are so many cells that start in the mutated state
Unilateral- the prevailing of the mutated cell is such a rare event that it doesn’t happen very often