Block C Flashcards
Renal and hepatic pharmacology
Which organ is cholesterol synthesized
liver
Name the most important enzyme for cholesterol synthesis
HMG CoA reductase
Name 4 functions of cholesterol
-vitamin D
-in cell membranes
-production of bile acids
-in sex hormones
Is LDL or HDL bad for you?
LDL
Name 4 drug therapies for high cholesterol
-statins
-bile acid sequestrants
-nicotinic acid
-ezetimibe
Compare pros and cons for statins (4 marks)
pro:
-increase HDL
-decrease LDL
-anti-inflammatory
con:
-very rare liver failure
Describe the mechanism for statins (3 marks)
-inhibits HMG-CoA reductase
-reduced total cholesterol levels and LDL levels
-increases HDL levels
In the liver, the _____ artery supplies 25% of total blood flow, _____ vein supplies 75% of blood flow
hepatic, portal
What is hepatitis? (3 marks)
is it the inflammation of the liver. this could be caused by a virus or liver damage through alcohol consumption.
Which 2 Hepatitis viruses are major causes of chronic hepatitis.
Hepatitis B and C
name 3 treatments for liver disease
-antiviral drugs to treat hepatitis
-steroids to reduce liver inflammation
-lifestyle changes
what are the 2 components of kidneys
-tubular component
-vascular component
why is the relationship between the 2 components in your kidneys important?
the mechanism by which the kidneys perform their function depend upon the relationship between these 2 components
what is the function of the kidneys? (2 marks)
-regulation of water and ion balance
-removal of waste products from blood (foreign chemicals)
what is the function of the liver? (3 marks)
-synthesizes and breaks down blood cells
-metabolize, detoxify and excrete both endogenous and exogenous compounds
-protein, lipid and carbohydrate homeostasis
