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Phase I Drugs List > Block 3 Drugs List > Flashcards

Block 3 Drugs List Flashcards

1
Q

Dopaminergics

Pharmacology of basal ganglia disorders

A

Generic Drug Name(s):
levodopa (L-dopa)

Principal MoA:
Dopamine precursor

Generic Drug Name(s):
pramipexole
ropinirole
rotigotine

Principal MoA:
Dopamine receptor agonist (synthetic)

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2
Q

Dopa-decarboxylase inhibitor

Pharmacology of basal ganglia disorders

A

Generic Drug Name(s):
carbidopa
benserazide

Principal MoA:
Stops breakdown of Levadopa in the periphery by inhibiting dopa-decarboxylase

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3
Q

COMT (catechol-O-methyl transferase) Inhibitor

Pharmacology of basal ganglia disorders

A

Generic Drug Name(s):
entacapone
tolcapone

Principal MoA:
Stops breakdown of DA in CNS by inhibition of COMT

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4
Q

MAOB (monoamine oxidase, B form) Inhibitor

Pharmacology of basal ganglia disorders

A

Generic Drug Name(s):
rasagiline
selegiline

Principal MoA:
Stops breakdown of DA in CNS by inhibition of MAOIB

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5
Q

Anticholinergics

Pharmacology of basal ganglia disorders

A

Generic Drug Name(s):
orphenadrine
procyclidine
trihexphenidyl

Principal MoA:
Muscarinic cholinergic receptor antagonist

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6
Q

Anti-Parkinsonism

Pharmacology of basal ganglia disorders

A

Generic Drug Name(s):
Amantadine

Principal MoA:
Antiviral. Glutamate (NMDA) receptor antagonist, dopamine agonist

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7
Q

Antipsychotics

Pharmacology of basal ganglia disorders

A

Generic Drug Name(s):
Separate Cards

Principal MoA:
Dopamine receptor antagonists

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8
Q

Dopamine-depleting drugs

Pharmacology of basal ganglia disorders

A

Generic Drug Name(s):
tetrabenazine

Principal MoA:
Blocks VMAT, preventing uptake of DA into vesicles

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9
Q

Weak analgesic/ antipyretic

Analgesic drugs

A

Generic Drug Name(s):
paracetamol

Principal MoA:
Non-selective COX inhibitor (CNS)

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10
Q

Non-steroidal anti-inflammatory drugs (NSAIDs)

Analgesic drugs

A 
Generic Drug Name(s):
aspirin
ibuprofen
diclofenac
naproxen

Principal MoA:
Non-selective COX inhibitor

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11
Q

COX2-selective NSAIDs

Analgesic drugs

A

Generic Drug Name(s):
celecoxib
etoricoxib

Principal MoA:
Selective COX-2 inhibitor

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12
Q

Weak opioid analgesics

Analgesic drugs

A

Generic Drug Name(s):
codeine
dihydrocodeine

Principal MoA:
Opioid receptor agonist

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13
Q

Strong opioid analgesics

Analgesic drugs

A

Generic Drug Name(s):
morphine
diamorphine

Principal MoA:
Opioid receptor agonist

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14
Q

Partial/mixed agonist-antagonist opioid analgesics

Analgesic drugs

A

Generic Drug Name(s):
buprenorphine

Principal MoA:
Opioid receptor agonist (μ)/antagonist (κ)

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15
Q

Opioid receptor antagonists

Analgesic drugs

A

Generic Drug Name(s): naloxone
naltrexone

Principal MoA:
Opioid receptor antagonist

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16
Q

Synthetic opioid

Analgesic drugs

A

Generic Drug Name(s):
tramadol

Principal MoA:
Opioid receptor agonist and serotonin/noradrenaline reuptake inhibitor

17
Q

Drugs used in management of opioid addiction

Analgesic drugs

A

Generic Drug Name(s):
methadone

Principal MoA:
Opioid receptor agonist

Generic Drug Name(s):
buprenorphine

Principal MoA:
Opioid receptor agonist (μ)/antagonist (κ)

18
Q

Drugs used to treat neuropathic pain

Analgesic drugs

A

Generic Drug Name(s):
gabapentin (AED)

Principal MoA:
Inhibits VDCC, Increases GABA transmission

Generic Drug Name(s):
pregabalin (AED)

Principal MoA:
Inhibits VDCC

Generic Drug Name(s):
carbamazepine (AED)

Principal MoA:
Sodium channel blocker

19
Q

Tricyclic Antidepressants (TCAs)

Pharmacology of Depression

A 
Generic Drug Name(s): 
amitriptyline
nortriptyline
imipramine
clomipramine

Principal MoA:
SRI, NRI, H1 antagonist, M1 antagonist, Adrenergic antagonist

20
Q

Selective serotonin reuptake inhibitors (SSRIs)

Pharmacology of Depression

A

Generic Drug Name(s):
sertraline
citalopram

Principal MoA:
Inhibits serotonin (5HT) reuptake pump
21
Q

Monoamine (A) oxidase inhibitors (MAOIs)

Pharmacology of Depression

A

Generic Drug Name(s):
moclobemide

Principal MoA:
Stops breakdown of monoamines in CNS. Reversible inhibitor of monoamine oxidase A (RIMA)

22
Q

Atypical Antidepressants

Pharmacology of Depression

A

Generic Drug Name(s):
reboxetine

Principal MoA:
NRI

Generic Drug Name(s):
bupropion

Principal MoA:
NDRI

Generic Drug Name(s):
agomelatine

Principal MoA:
melatonin agonist

Generic Drug Name(s):
venlafaxine

Principal MoA:
SNRI

Generic Drug Name(s):
mirtazapine

Principal MoA:
α2-Adrenergic antagonist

23
Q

Anxiolytic (adjunct)

Pharmacology of Depression

A

Generic Drug Name(s):
buspirone (anxiolytic)

Principal MoA:
5HT1a partial agonist

24
Q

1st Generation Antipsychotics

Antipsychotics

A

Generic Drug Name(s):
chlorpromazine
haloperidol

Principal MoA:
Selective dopamine (D2) receptor antagonist
25
Q

2nd Generation Antipsychotics

Antipsychotics

A

Generic Drug Name(s):
amisulpride

Principal MoA:
Serotonin (5HT7) and dopamine (D2) antagonist

Generic Drug Name(s):
risperidone
clozapine

Principal MoA:
Serotonin (5HT2A) and dopamine (D2) antagonist

26
Q

3rd Generation Antipsychotics

Antipsychotics

A

Generic Drug Name(s):
aripiprazole

Principal MoA:
Partial agonist at 5HT and DA receptors

27
Q

Anxiolytic (adjunct in depression)

Anxiolytics and related drugs

A

Generic Drug Name(s):
buspirone (anxiolytic)

Principal MoA:
5HT1a partial agonist

28
Q

Muscle relaxants/sedatives/anxiolytic-hypnotic

Anxiolytics and related drugs

A

Generic Drug Name(s):
zolpidem (‘Z-drug’)

Principal MoA: 
GABA PAM (mechanistically identical to BDZ)

Generic Drug Name(s):
temazepam (BDZ)

Principal MoA:
GABA PAM

Generic Drug Name(s):
dexmedetomidine

Principal MoA:
α2-adrenergic receptor agonist

Generic Drug Name(s):
alfentanil
fentanil (or ‘-yl’)
remifentanil

Principal MoA:
Opioid receptor agonist (short-acting)

29
Q

Symptom reduction (autonomic)

Anxiolytics and related drugs

A

Generic Drug Name(s):
propranolol

Principal MoA:
β-blocker

30
Q

Anti-epilepsy drugs (AEDs)

Drugs used for epilepsy

A

Generic Drug Name(s):
sodium valproate
lamotrigine
carbemazepine

Principal MoA:
Sodium channel blocker

Generic Drug Name(s):
Calcium channel blocker (T-type)

31
Q

Benzodiazepines (BDZ)

Drugs used for epilepsy

A

Generic Drug Name(s):
midazolam
lorazepam
diazepam

Principal MoA: 
GABA PAM (γ-subunit)
32
Q

BDZ Antagonist

Drugs used for epilepsy

A

Generic Drug Name(s):
flumazenil

Principal MoA:
Competitive antagonist at BDZ site

33
Q

Barbiturates (Barb)

Drugs used for epilepsy

A

Generic Drug Name(s):
phenobarbitone
pentobarbitone
primidone

Principal MoA: 
GABA PAM (β -subunit)
34
Q

Adjuncts

Drugs used for epilepsy

A

Generic Drug Name(s):
vigabatrin

Principal MoA:
Inhibits GABA breakdown by GABA transaminase

Generic Drug Name(s):
tiagabin

Principal MoA:
GABA reuptake inhibitor

Generic Drug Name(s):
levetiracetam

Principal MoA:
Unclear MoA

35
Q

Anticholinesterases

Drugs used for dementia

A

Generic Drug Name(s):

donepezil
galantamine
rivastigmine

Principal MoA:
Inhibitor of acetylcholinesterase (reversible)

36
Q

Glutamate (NMDA) receptor antagonists

Drugs used for dementia

A

Generic Drug Name(s):
memantine

Principal MoA:
VD blocker of NMDA receptors (NMDA NAM)

37
Q

Antimicrobial drugs

Drugs used for CNS Infection

A

Generic Drug Name(s):
Ceftriaxone (see antibiotics, Block 4)

Principal MoA:
Inhibits synthesis of cell walls in bacteria

Generic Drug Name(s):
amoxicillin (see antibiotics, Block 4)

Principal MoA:
Induces cell lysis by blocking last stages of cell wall synthesis

38
Q

Corticosteroid (see also Block 2)

Drugs used for CNS Infection

A

Generic Drug Name(s):
dexamethasone

Principal MoA:
Glucocorticoid receptor agonist

Phase I Drugs List (5 decks)

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