Block 3 Flashcards
1
Q
sclera
A
- tough, outer layer of the eye
- Gr. skleros, hard
2
Q
cornea
A
- transparent, focusing apparatus of the eye
- performs 2/3 of the light bending
- is innervated by many nerve endings
3
Q
lens
A
- performs the final 1/3 of light bending for proper focus
- shape controlled by the ciliary muscles
4
Q
ciliary muscles
A
- control the shape of the lens
- by contracting they cause the lens to become more convex which sharpens the visual image on the retina
5
Q
accommodation
A
The change in the shape of the lens is controlled by the ciliary muscles inside the eye. Changes in contraction of the ciliary muscles alter the focal distance of the eye, causing nearer or farther images to come into focus on the retina; this process is known as accommodation.
6
Q
what controls how much light enters the eye by adjusting the size of the pupil?
A
-the smooth muscles of the iris
7
Q
aqueous humor
A
-fills in the space in front of the lens and between the iris and the lens
8
Q
vitreous humor
A
fills in the space between the lens and the retina
9
Q
what muscles control eye position in the socket?
A
-extraocular skeletal muscles
10
Q
retina
A
- is part of the CNS and derived from neural tube
- laminated and 250 microns thick
- 3 primary cell layers arranged inside out
11
Q
the pigmented epithelium behind the retina
A
- absorbs light to prevent backscatter
- recycles retinal as part of the transduction process
- possesses tight junctions and forms a blood-retina barrier
12
Q
name the principle cells of the retina
A
- photoreceptors: rods and cones
- local circuit neurons: bipolar, horizontal, and amacrine
- projection neurons: ganglion cells
13
Q
fovea
A
- point of the retina with the highest visual acuity
- it lies in the center of the retina (aka the macula )
- there is a higher density of photoreceptors there
14
Q
papilla
A
aka optic disk
- where axons of ganglion cells are bundled to form optic nerve
- since no photoreceptors are there, there is a blind spot
15
Q
direct vertical pathway
A
-from photoreceptor to bipolar to ganglion cell
16
Q
indirect lateral pathway
A
-involves horizontal spread of information through local circuit neurons, the horizontal and amacrine cells
17
Q
what is the overall convergence ratio of rods and cones to ganglion cells
A
100 to 1
18
Q
what photoreceptor dominates at the fovea?
A
cones
19
Q
name the ways to increase visual acuity
A
- absence of intervening cells
- increased density of photoreceptors
- high concentration of cones
- low degree of convergence from photorecetors to ganglion cells
20
Q
visual field
A
-part of the environment impinging upon the whole retina at any one time
21
Q
binocular field
A
-subset of the visual field that impinges upon both eyes at the same time
22
Q
monocular field
A
-parts of the visual field outside of the overlap of the binocular field
23
Q
retinal field
A
- reversed image of the visual field that is projected onto the retina
- medial part: nasal field
- lateral: temporal field
24
Q
receptive field
A
-part of the retina that when stimulated by light alters the electrical activity of a neuron
25
what is the photopigment in rods
-rhodopsin
26
what is the photopigment in cones?
-photopsin: either blue, red, or green
27
rhodopsin
- an aldehyde derivative of vitamin A
| - is sensitive to electromagnetic radiation from 400-700 nm
28
photoreceptors release transmitter from their ____ onto bipolar cells
-synaptic endings
29
what photoreceptor is responsible for night vision
-rods due to large outer segments, and more photopigment
30
in the dark, rhodopsin is ____, ___ is high, and ion channels are open
-inactive, cGMP is high, ion channels are open
31
in the light, what happens in the outer segment of the photoreceptor
- light bleaches rhodopsin
- opsin decreases cGMP
- Na+ channels close and the cell hyperpolarizes
32
on center ganglion cells
- increase activity when the center of its receptive field is illuminated and decrease activity when its surround is illuminated
- responds best to rapid increases in illumination intensity and to objects brighter than the background
33
ganglion cells show ___ as a result of ____ in the circuit
-center-surround antagonism as a result of lateral inhibition
34
on-center ganglion cell
-increases activity when the center of its receptive field is illuminated and decreases activity when the surround is illuminated
35
off center ganglion cells
-decrease activity when the center of its receptive field is illuminated and increases activity when its surround is illuminated
responds best to: rapid decreases in illumination intenisty and to objects that are darker than the background
36
in the dark, glutamate released from the photoreceptor _____ the off-center bipolar cell and _____ the on-center bipolar cell
- depolarizes the off-center bipolar cell
| - hyperpolarizes the on-center bipolar cell
37
how is surround antagonism for cones achieved?
-lateral inhibition from horizontal cells
38
in the dark horizontal cells are ____ by ____ which is released by photoreceptors
depolarized by glutamate
39
depolarized horizontal cells release ___ onto the __-synaptic terminals of _____
release GABA onto the presynaptic terminals of photoreceptors
40
retinal ganglion cells: M cells
- magnocellular
- large cell bodies, dendritic trees and axons
- large receptive field sizes and are slowly adapting
- sensitive to: contrast illumination, large objects, and movement
41
retinal ganglion cells: P cells
- parvocellular
- small cell bodies, dendritic trees, and axons
- more numerous with small receptive fields
- rapidly adapting
- specially sensitive to: fine spatial resolution, form, and color for slow events
42
what thalamic subdivision is dedicated to relaying visual information to the cortex?
-lateral geniculate nucleus
43
axons of ganglion cells from nasal parts of the retina cross the midline at the
- optic chiasm
| * *information from the right visual field is projected to the left thalamus and cortex
44
In the lateral geniculate nucleus, the contralateral eyes innervate
layers 1,4, and 6
45
In the lateral geniculate nucleus, the ipsilateral eyes innervate
2,3, and 5
46
scotoma
hole in the visual field
47
olfactory and gustation involve ____ of chemical to ____ energy
- transduction
| - electrical
48
olfactory sensory neurons are located in the ____ at the top of the nasal cavity
olfactory epithelium
49
what makes up the olfactory cranial nerve (I)?
axons from the primary olfactory neurons
50
In the olfactory system, the axons from the ___ project through the __(bone)__ into the ____
- primary olfactory neurons
- cribriform plate of ethmoid bone of skull
- olfactory bulb
51
T or F: individual primary olfactory neuronal axons are myelinated
False: the unmyelinated axons of primary olfactory neurons are ensheathed by Schwann-cell like olfactory ensheathing cells
52
the olfactory bulb consists of series of ___
glomeruli
53
Within the ___, olfactory axons contact the dendrites of ____ cells
glomerulus
| -mitral
54
Mitral cells send their axons through the ___ to the brain
olfactory tract
55
name the 3 cells of the olfactory epithelium
-basal cells, supporting cells, and primary olfactory cells
56
olfactory neurons are replaced every __ days, with new neurons proliferating from the ___ cells
- 30-60 days
| - basal cells
57
describe primary olfactory neurons
-bipolar cells with ciliated processes on their dendrites that contain the specific olfactory receptors
58
molecular receptive range
-the range of odorant molecules that will alter the activity of the cell in the olfactory system
59
describe how olfactory system generates a map that spatially encodes odors
-primary olfactory neurons with the same receptor appear to be randomly localized in the olfacory epithelium, but they converge onto a common glomerulus in the olfactory bulb
60
primary visual cortex
- Brodman's area 17
| - striate cortex or V1
61
A map of the ___ field is projected onto the primary visual cortex by ____
- retinal
| - lateral geniculate neurons
62
the ____ is represented by the largest proportion of lateral geniculate neurons, optic radiation fibers, and primary visual cortical neurons
-fovea
63
Inputs from LGN terminate mainly on stellate cells in layer __ of __
-layer 4 of V1
64
Do axons of magnocellular and parvolcellular layers of the geniculate terminate in same or separate sublayers of layer 4 of V1?
-separate sublayers
65
stellate cells in layer 4 project to
-pyramidal neurons in superficial or deep layers
66
the receptive fields of simple cortical cells in V1
- consist of elongated centers (on or off characteristics)
- preferred orientations
- antagonistic suuround
- stimulus must have proper orientation, size, and position!!
67
the axons of mitral/tufted cells project through the ___- to target cells in the _____
- olfactory tract
| - rhinencephalon
68
the ____ provides interhemispheric communication between the two olfactory bulbs via the ___ commissure
- anterior olfactory nucleus
| - anterior commissure
69
the olfactory tubercle projects to the ___ nucleus of the thalamus, which relays information to the orbitofrontal cortex
-mediodorsal nucleus of the thalamus
70
What cortex was thought to be the main olfactory processing cortex, but now appears to be involved in processing exploratory olfactory info from active sniffing
piriform cortex
71
Name important regions for the emotional conditioning and memory formation
-temporal lobe structures, amygdala, and entorhinal cortex
72
reflexes
-rapid, stereotyped, and involuntary
73
rhythmic motor patterns
-voluntarily initiated and terminated, but maintained through reflexes
74
voluntary movements
are purposeful and learned
75
agonist
-the prime movers
76
synergistic muscles
cooperate to produce movement in the same direction as agonsist
77
antagonists
-muscles that decelerate agonist movement and move limbs in opposing directions
78
Axial muscles
-move the trunk and maintain posture
79
proximal muscles
- move the shoulder, elbow, pelvis, and knee
| - posture, locomotion, and strong arm force
80
distal muscles
move the hands and feet, fingers and toes, and eyes and face
| -facial expression, maintain binococular vision, and fine manipulation of objects
81
describe the hierarchy of the motor system
- cortex: general commands
- brainstem: regulates spinal motor neuron activity
- spinal cord: integrates local and descending drive to motor neurons
82
basal ganglia
plan appropriate movements
83
cerebellum
-correct errors and are involved in motor learning
84
Motor neurons are ____ organized
- somatotopically
| - those supplying proximal/trunk/axial muscles are located more medially than those supplying distal muscles
85
Where are flexor muscle motor neurons located compared to extensor?
flexors tend to be more dorsal
86
muscle paresis
- muscle weakness
| - can result when a single spinal nerve is damaged
87
insecticides and nerve gases
- block AChEase
- The inhibition of the enzyme leads to accumulation of ACh in the synaptic cleft resulting in over-stimulation of nicotinic and muscarinic ACh receptors and impeded neurotransmission. The typical symptoms of acute poisoning are agitation, muscle weakness, muscle fasciculations, miosis, hypersalivation, sweating.
88
botulinum toxin
-blocks release of ACh
89
Black widow spider venom
-overstimulates the release of ACh
90
Curare
-blocks ACh receptors
91
AChEase inhibitors are used to treat
myasthenia gravis:
| a disorder characterized by muscle weakness and autoimmunity for ACh receptor
92
twitch
-the contraction created by a single action potential in a muscle fiber
93
Renshaw cell
-an inhibitory spinal interneuron which is activated by a motor neuron inhibitng its own activity
94
tetanospasmin
- a neurotoxin released by clostridium tetani that destroys Renshaw cell synapses with motor neurons
- this results in unrelieved motor neuron firing and muscle tetanus
95
the orientation selectivity of cortical cells has what kinds of organization
-columnar organization
96
orientation columns have what kind of organization
-pinwheel
97
dorsal stream
- "where" pathway
- originates primarily from retinal M ganglion cells
- processes spatial features and movement
- carried out via projections to posterior parietal cortex
98
the ventral stream
- what pathway
- primarily from retinal p ganglion cells
- object recognition and involves projections to the inferior temporal cortex
99
agnosia
- inability to recognize objects
| - results from damage to inferior temporal cortex or other parts of ventral stream
100
akinetopsia
- deficits in detecting motion
| - results from damage to posterior parietal cortex
101
prosopagnosia
- inability to recognize people from their face
| - results from damage to ventral stream pathway
102
Tectospinal pathway
Origin: superior colliculus
Main input: visual, auditory, somatosensory
Muscle Group: eye/neck
Function: orienting reflexes, saccadic eye movements
103
Lateral Vestibulospinal Pathway
Origin: lateral vestibular nucleus
Main input: otolith organs
Muscle groups: trunk and proximal extensors
Function: feedback postural controls and adjustments of spinal reflexes
104
Medial vestibulospinal pathway
Origin: medial vestibular nucleus
Main input: otolith organs and Semicircular canals
Muscle groups: neck
Function: coordinate neck and head movements with body
105
Reticulospinal tract
Origin: reticular formation
Main input: visual, auditory, somatosensory, vestibular, cortical, cerebellar
Muscle groups: trunk/proximal extensors
Function: feedforward postural adjustment of spinal reflexes, orienting reflexes, crude voluntary movement
