Block 15 - part 2 Flashcards
GI cancer prevalent in middle east and china
oesophageal
GI cancer prevalent in russia
gastric
GI cancer prevalent in western world, e.g. UK
colon
dietary intake which increases risk of colorectal cancer
fat intake
evidence base for ‘5 a day’
observational epidemiology that average fruit/veg intake of less than 200g associated with increased risk of cancer, but possibly little additional benefit beyond 400g/day, very little evidence that 5 a day have impact on cancer
relationship between beta carotene and cancer
beta carotene found in fruit and veg, cohort study indicated protective relationship against cancer, RCT showed increased risk of cancer, cohort groups had reduced risk due to confounding factors
problems with measuring diet
random error, homogeneity of exposure, bias, confounding
different measures of diet
food disappearance data, household survey, individual survey
pros of food frequency questionnaires
captures usual diet and less work to code/compete
cons of food frequency questionnaires
doesn’t record actual diet as eaten, overstimulates fruit and veg, poor measure of energy intake, less flexible
food frequency questionnaires
limited checklist of foods and beverages with a frequency response section for subjects to report how often each item was consumed over a specified period of time
pros of diet diaries
records diet as eaten, better estimate of energy and absolute intake, more flexible
cons of diet diaries
required effort to complete and expensive to code
main dietary associations with oesophageal cancer
alcohol, obesity
main dietary associations with stomach cancer
possible salted preserved foods
main dietary associations with pancreatic cancer
overweigh obesity
main dietary associations with hepatic cancer
aflatoxin contamination
main dietary associations with colorectal cancer
preserved and red meat, alcohol, body fat
main dietary associations with breast cancer
alcohol, overweight
main dietary associations with urologic cancer
high calcium