Block 13- Week 1

Question 1

Paclitaxal

Answer 1

Micro tubule stabilisation agent

Taxoid antineoplastic agent - first line for advanced ovarian carcinoma and breast cancer

Binds to B subunit of Tubulin causing hyper stabilisation of micro tubule reorganising micro tubule cytoskeleton

Also induces apoptosis in cancer cells by binding to bcl-2 blocking anti apoptotic function of Bcl-2 and thus allowing apoptosis to proceed

Question 2

Cisplatin

Answer 2

Anti neoplastic alkylating agent

Cancer

Cell cycle non specific

Attach alkyl groups to DNA bases resulting in DNA fragmentation and preventing DNA synthesis

Question 3

Isoniazid

Answer 3

Highly specific bactericidal agent which targets mycobacterium - M. Tuberculosis , M.bovis etc

Prodrug activated by bacterial catalase , once activated inhibits synthesis of mycoloic acids - essential component of bacterial cell wall

Question 4

Ethambutol

Answer 4

Bactericidal agent

Oral chemotherapeutic agent against mycobacterium incl M. Tuberculosis

Inhibits arabinosyl transferase which is involved in cell wall biosynthesis - inhibiting cell wall complex production leading to an increase in cell wall permeability

Question 5

Rifampicin

Answer 5

Broad spectrum bactericidal antibiotic targeting both gram positive and gram negative

Inhibition of DNA dependent RNA polymerase leading to suppression of RNA synthesis and cell death

Question 6

Pyrazinamide

Answer 6

Treat TB

Active only against M . Tuberculosis

Gets activated to pyrazinoic acid in the bacilli

Interferes with fatty Acid synthase reducing new fatty acid synthesis required for growth and replication

Question 7

Ciprofloxacin

Answer 7

Broad spectrum antibiotic

Is a quinolone

Inhibition of topoisomerase II and topoisomerase IV which are required for bacterial DNA replication , transcription , repair etc