Block 11- Week 3

Question 1

Tetracycline

Answer 1

Broad spectrum antibiotic

30S inhibitor

Question 2

Gentamicin

Answer 2

Broad spectrum antibiotic

30S inhibitor

Aminoglycoside
Gram Negative bacteria

Can cause significant ear and kidney damage

Question 3

Ampicillin

Answer 3

Pencillin beta lactam antibiotic

Transpeptidase inhibitor

Gram positive infections

Inhibit cell wall synthesis by binding to PBPs and preventing cell wall synthesis and causing cell lysis

Question 4

Sodium valproate

Answer 4

Anti-convulsant

GABA receptor agonist

Fatty acid

Treat epilepsy

Antiepileptic drug and mood stabiliser

Question 5

Ethanol

Answer 5

Neuronal depressant

Sedative effects by binding to GABA receptors

Also binds to ACH , serotonin , NMDA receptors

Rarely used therapeutically as fomepizole had replaced it for methanol / ethylene glycol poisoning

Question 6

Cocaine

Answer 6

Anaesthetic- inhibiting excitation of nerve endings of blocking conduction in peripheral nerves - by inactivating sodium channels

vasoconstrictor - blockade of NAR reuptake in the ANS

Noradrenaline reuptake inhibitor

Sodium channel blocker

Question 7

Lithium

Answer 7

Mood stabilising agent

Sodium analogue

Treat bipolar disorder

Question 8

Thalidomide

Answer 8

Immunomodulatory agent

Anti-angiogenic effects

Changes concentrations of TNFa also affect VEGF

Teratogenic effects on humans

Treat cancer and leprosy