BLOCK 12 WEEK 7 Flashcards
EPILEPSY
- Epilepsy is a condition characterised by seizures. Seizures are transient episodes of abnormal electrical activity in the brain.
TYPES OF SEIZURES
-Generalised tonic-clonic seizures
- Partial seizures (or focal seizures)
- Myoclonic seizures
-Tonic seizures
- Atonic seizures
GENERALISED TONIC- CLONIC SEIZURES
- Generalised tonic-clonic seizures involve tonic (muscle tensing) and clonic (muscle jerking) movements associated with a complete loss of consciousness.
- Typically, the tonic phase comes before the clonic phase.
- They are also called grand mal seizures.
- Before the seizure, patients might experience aura, an abnormal sensation that gives a warning that a seizure will occur. There may be tongue biting, incontinence, groaning and irregular breathing.
- After the seizure, there is a prolonged post-ictal period, where the person is confused, tired, and irritable or low.
What percentage of people with epilepsy have focal seizures?
60% of people with epilepsy have focal seizures
60-70% of focal seizures originate in the temporal lobe
PARTIAL/FOCAL seizures
- Partial seizures (or focal seizures) occur in an isolated brain area, often in the temporal lobes.
- They affect hearing, speech, memory and emotions. ç
- Patients remain awake during partial seizures. They remain aware during simple partial seizures but lose awareness during complex partial seizures.
There are various symptoms associated with partial seizures, depending on the location of the abnormal electrical activity:
- Déjà vu
- Strange smells, tastes, sight or sound sensations
- Unusual emotions
- Abnormal behaviours
MYOCLONIC SEIZURE
- Present with sudden, brief muscle contractions, like an abrupt jump or jolt.
- They remain awake.
- Myoclonic seizures can occur as part of juvenile myoclonic epilepsy in children.
TONIC SEIZURES
- Tonic seizures involve a sudden onset of INCREASED MUSCLE TONE where the entire BODY STIFFENS .
- This results in a fall if the patient is standing, usually backwards. They last only a few seconds, or at most a few minutes.
ATONIC SEIZURE
- Atonic seizures (causing “drop attacks”) involve a SUDDEN LOSS OF MUSCLE TONE, often resulting in a fall.
- They last only briefly, and patients are usually aware during the episodes. They often begin in childhood. They may be indicative of Lennox-Gastaut syndrome.
SEIZURES COMMON IN CHILDREN
- Absence seizures
-Infantile spasms
- Febrile convulsions
ABSENCE SEIZURES
Absence seizures are usually seen in children.
The patient becomes blank, stares into space, and then abruptly returns to normal.
During the episode, they are unaware of their surroundings and do not respond.
These typically last 10 to 20 seconds. Most patients stop having absence seizures as they get older.
INFANTILE SPASMS
- Infantile spasms are also known as West syndrome.
- It is a rare (1 in 4,000) disorder starting at around six months of age.
- It presents with clusters of full-body spasms.
- Hypsarrhythmia is the characteristic EEG finding. It is associated with developmental regression and has a poor prognosis.
- Treatment is with ACTH and vigabatrin.
FEBRILE CONVULSIONS
Febrile convulsions are tonic-clonic seizures that occur in children during a high fever.
They are not caused by epilepsy or other pathology (e.g., meningitis or tumours).
Febrile convulsions occur in children aged between 6 months and 5 years.
Febrile convulsions do not usually cause any lasting damage. One in three will have another febrile convulsion.
They slightly increase the risk of developing epilepsy.
IT IS IMPORTANT TO DISTINGUISH SEIZURES FROM OTHER CONDITIONS
Vasovagal syncope (fainting)
Pseudoseizures (non-epileptic attacks)
Cardiac syncope (e.g., arrhythmias or structural heart disease)
Hypoglycaemia
Hemiplegic migraine
Transient ischaemic attack
DIAGNOSING EPILEPSY
An electroencephalogram (EEG) shows typical patterns in different forms of epilepsy and supports the diagnosis.
MANAGEMENT OF EPILEPSY
- Patients and families presenting with seizures are advised about safety precautions and recognising, managing and reporting further seizures. Safety precautions include:
-The DVLA will remove their driving licence until specific criteria are met (e.g., being seizure-free for one year)
- Taking showers rather than baths (drowning is a major risk in epilepsy)
-Particular caution with swimming, heights, traffic and dangerous equipment
TREATMENT
Treatment depends on the type of seizure, guided by a specialist.
Treatment aims to be seizure-free on the minimum anti-epileptic medications, ideally monotherapy with a single drug.
First-line therapies depend on the type of seizure, based on the NICE guidelines (2022):
- 60-70% of pateints become seizure free after treatment with anticonvulsants
FRONTAL LOBE FUNCTION