Blistering Diseases Flashcards
1
Q
Pemphigus vulgaris
- IgG against?
- where does it break?
- Nikolsky sign
- row of tombstones
- pattern on IF
A
- IgG against desmogleins 1 and 3
- suprabasal split
- pressure on blister causes lateral spread of lesion
- basal cells left over under the blister
- reticular
2
Q
Pemphigus foliaceus
A
-
3
Q
pemphigus vetegans
A
-
4
Q
bullous pemphigoid
A
- BP antigen 1 and 2 of the hemidesmosome
- subepidermal blister (full thickness)
- heal without scarring
5
Q
dermatitis herpetiformis
A
- IgA to transglutaminases bind to TG in gut, cross react with reticulin fibers in the skin
- men more often than women
- gluten sensitive enteropathy (dafuq)
- subepidermal blister
- IF in tips of dermal papillae (antiendomysial abs)
6
Q
epidermolysis bullosa
- simplex
- junctional
- dystrophic
- non-herlitz junctional
A
-blisters form at pressure points - -lamina lucida -collagen VII -laminin Vbeta3
7
Q
porphyria cutanea tarda - - -type I -type II
A
- women on oral contraceptives, Hep C, sunlight exposure
- uroporphyrinogen decarboxylase (UROD)
- acquired, drug or chemical exposure
- genetic
- subepidermal vesiculation
8
Q
acne vulgaris
A
- obstruction of sebaceous glands
- closed comedones,
- open comedones
9
Q
acne rosacea
-four stages
A
- flushing, persistent redness, pustules, rhinophyma
- perifollicular infiltrate of lymphocytes
10
Q
panniculitis
A
-inflamed fat lobules
11
Q
erythema nodosum
A
- inflamed CT septae separating fat lobules
- fever malaise, joint pain
- widening of septa from fibrin, edema and neutrophilic infiltrate
12
Q
Warts
A
- skin to skin contact
- intralesial brown-black dots thromboses vessels
13
Q
mulloscum contagiosum
A
- smooth dome shaped papillose with central umbilication
- cheesy core
14
Q
impetigo
- bullous
- non-bullous
A
-accumulation of neutrophils under stratum corneum, attacking staph aureus
15
Q
scabies
A
- worst itch they’ve ever had
- delayed type IV HS rxn, usually at night
