Blistering Diseases

Question 1

Pemphigus vulgaris

• IgG against?
• where does it break?
• Nikolsky sign
• row of tombstones
• pattern on IF

Answer 1

• IgG against desmogleins 1 and 3
• suprabasal split
• pressure on blister causes lateral spread of lesion
• basal cells left over under the blister
• reticular

Question 2

Pemphigus foliaceus

Answer 2

-

Question 3

pemphigus vetegans

Answer 3

-

Question 4

bullous pemphigoid

Answer 4

• BP antigen 1 and 2 of the hemidesmosome
• subepidermal blister (full thickness)
• heal without scarring

Question 5

dermatitis herpetiformis

Answer 5

• IgA to transglutaminases bind to TG in gut, cross react with reticulin fibers in the skin
• men more often than women
• gluten sensitive enteropathy (dafuq)
• subepidermal blister
• IF in tips of dermal papillae (antiendomysial abs)

Question 6

epidermolysis bullosa

• simplex
• junctional
• dystrophic
• non-herlitz junctional

Answer 6

-blisters form at pressure points
-
-lamina lucida
-collagen VII
-laminin Vbeta3

Question 7

porphyria cutanea tarda
-
-
-type I
-type II

Answer 7

• women on oral contraceptives, Hep C, sunlight exposure
• uroporphyrinogen decarboxylase (UROD)
• acquired, drug or chemical exposure
• genetic
• subepidermal vesiculation

Question 8

acne vulgaris

Answer 8

• obstruction of sebaceous glands
• closed comedones,
• open comedones

Question 9

acne rosacea

-four stages

Answer 9

• flushing, persistent redness, pustules, rhinophyma

- perifollicular infiltrate of lymphocytes

Question 10

panniculitis

Answer 10

-inflamed fat lobules

Question 11

erythema nodosum

Answer 11

• inflamed CT septae separating fat lobules
• fever malaise, joint pain
• widening of septa from fibrin, edema and neutrophilic infiltrate

Question 12

Warts

Answer 12

• skin to skin contact

- intralesial brown-black dots thromboses vessels

Question 13

mulloscum contagiosum

Answer 13

• smooth dome shaped papillose with central umbilication

- cheesy core

Question 14

impetigo

• bullous
• non-bullous

Answer 14

-accumulation of neutrophils under stratum corneum, attacking staph aureus

Question 15

scabies

Answer 15

• worst itch they’ve ever had

- delayed type IV HS rxn, usually at night

Question 16

xanthelasma

Answer 16

-nodule on the achilles

Question 17

mongolian spot

Answer 17

• nueral crest cells interrupted in migration

- disappear in childhood

Question 18

cherry angioma

Answer 18

-increase with age

Question 19

hemangioma

Answer 19

• benign vascular tumor

- blanch!

Question 20

hemangioma of infancy

Answer 20

• do no treat unless they block the ears, eyes, or larynx

- they regress!!!!!

Question 21

alopecia

• anagen
• catagen
• telogen

Answer 21

• androgenetic
• tinea capitis
• telogen effluvium
• alopeica areata

Question 22

xeroderma pigmentosum

Answer 22

-

Question 23

chediak higashi

Answer 23

-failure of phagolysosome fusion

Question 24

wiskott-aldrich

Answer 24

-eczema, thrombocytopenic pupura

Question 25

albinism

Answer 25

-absence of tyrosinase