Benign epithelial tumors

Question 1

seborrheic keratosis (SK) (most common benign tumor in ppl over 40)

• tumor progression
• sign of Leser-Trelat
• which type of cell is overgrowing?
• how does this effect the skin surface?
• where else does one find keratin in these tumors?

Answer 1

• start as light brown, flat macules, progress to velvety, waxy, veracious surface
• multiple eruptive SK’s could indicate an internal malignancy
• basaloid cells
• eventually become keratinocytes and overproduce keratin
• find keratin cysts “horn cysts”

Question 2

dermatosis papulosa nigra

• subtype of
• common in which race?
• Tx?

Answer 2

• SK
• occurs most often in african americans
• no treatment necessary

Question 3

acanthosis nigrans

• first clinical sign?
• which layer first becomes hyper plastic?
• where is it found?
• when do you worry about malignancy?
• what are the benign types associated with?

Answer 3

• hyper pigmentation
• stratum spinosum
• folds in the neck, axilla, and groin
• when the patient is middle aged or older, could indicate visceral malignancy
• endocrine abnormalities (DM)

Question 4

epiermal inclusion cyst

• common location/age
• cyst wall composure and contents
• inflamed vs. quiet

Answer 4

• head and neck of children
• cyst wall looks like normal epidermis, contains keratin
• may be surgically excised