Bleeding DOs

Question 1

VWF

Answer 1

• stored in endothelial cells and Platelets
• Mediates PLT adhesion to collagen fibers
• Prevents breakdown of Factor VIII (intrinsic pathway)

Question 2

Von Willebrand Disease Tx (Mild/Mod)

Answer 2

Desmopressin (DDAVP)

• ADH analog
• stim release of VWF from endothelial cells

Question 3

Von Willebrand Disease Tx (SEVERE)

Answer 3

Humate-P (VWF concentrate)

Question 4

Von Willebrand Dz Type I & II are Autosomal _____

Answer 4

Dominant

& MC than Type III

Question 5

Von Willebrand Dz Type III is Autosomal ____

Answer 5

Recessive

Question 6

Hemophilia A & B are _____ inherited

Answer 6

X-linked (Recessive)

Mostly affecting MALES

Question 7

Hemophilia ___ is “Classical” and is a Factor VIII (8) Deficiency

Answer 7

A

Question 8

Hemophilia A is a Factor ____ defiicency

Answer 8

8

Question 9

Hemophilia B is a Factor ____ deficiency

Answer 9

9

Question 10

Hemophilia ____ is More Common

Answer 10

A

More common B

Question 11

Does Hemophilia or VWD have an abnormal bleed time?

Answer 11

VWD bc it also affects platelet adhesion

Question 12

Hemophilia #1 Tx

Answer 12

Factor VIII/IX Replacement (Factor concentrate or Cryoprecipitate)

Question 13

Hemophilia Tx:

To prepare for a MAJOR Sx, the Factor 8 level must be raised to _____% and then maintained above 50%

Answer 13

100%

Question 14

Mild Hemophilia A Tx to help avoid complications from giving blood products?

Answer 14

Desmopressin (DDAVP)

Question 15

Hemophilia Tx:

2 Tx for Dental extraction bleeding prophylaxis

Answer 15

Aminocaproid acid
Tranexamic acid

take either for 1 week

Question 16

Factor ___ Deficiency:
Ashkenazi Jew has severe bleeding after Trauma or Sx

Answer 16

XI