Bisphosphonates for Cancer Treatment

Question 1

MOA of bisphosphonates (3)

Answer 1

1. Target osteoclasts
2. Inhibit osteoclast formation and activity
3. Produces greatest bone density increases of all osteoporosis therapies

Question 2

Bisphosphonates:

What do the oral drugs treat?

Answer 2

Prevent and treatment of osteoporosis

Question 3

Bisphosphonates:

Three Oral Drugs

Answer 3

Alendronate
Risedronate
Ibandronate

Question 4

Bisphosphonates:

What do the IV treat?

Answer 4

Treatment of bone pathologies

Question 5

Bisphosphonates:

Four IV Drugs

Answer 5

Etidronate Disodium
Pamidronate
Zoledronic Acid
Tiludronate

Question 6

Bisphosphonates:

The specific drug used for osteoporosis prevention

Answer 6

Zoledronic acid

Question 7

Osteonecrosis=

Answer 7

Death of the bone

Question 8

IV Bisphosphonates are used for what types of cancers?

Answer 8

Treatment of advanced breast and prostate cancers and metastatic cancers to the bones

Question 9

IV Bisphosphonates: What do they help with?

Answer 9

Help with relieving pain and high calcium levels caused by cancer that has spread to the bone

Question 10

IV Bisphosphonates:

What do these help slow/delay?

Answer 10

Help slow the growth of cancer that has spread to the bones and help delay or prevent fractures

Question 11

IV Bisphosphonates:

What has evidence shown that these drugs exert?

Answer 11

Antitumor properties

Question 12

Adverse skeletal events are common in patients with _____ cancer, and often lead to other complications, including death.

Answer 12

Prostate

Question 13

Five breast cancer benefits of IV Bisphosphonate Therapy

Answer 13

1. Anti-angiogenesis that cut off blood supply to tumors
2. Slowing of tumor progression
3. Stimulation of immunity
4. Antimetastatic
5. Increase disease-free survival

Question 14

Risk for BPONJ with oral meds is ____

Answer 14

Low

Question 15

Denosumab is a new _____ drug

Answer 15

Osteoporosis

Question 16

Denosumab is NOT a _______. It is a ____ ____

Answer 16

Bisphosophonate; monoclonal antibody

Question 17

Denosumab Indication

Answer 17

Treatment of osteoporosis in postmenopausal women at high risk for fractures

Question 18

Denosumab investigational in preventing bone loss associated with

Answer 18

1. Androgen deprivation therapy in non-metastatic prostate CA
2. Aromatase inhibitor therapy in breast CA
3. Treatment of bone destruction caused by RA

Question 19

Denosumab MOA

Answer 19

Receptor blocker on osteoclasts

Blocks interaction between ligand and receptor (RANK) located on osteoclast surfaces and prevents osteoclast formation

Question 20

Denosumab leads to _____ bone resportion and _____ bone mass

Answer 20

Decreased bone resportion and increased bone mass

Question 21

Denosumab: Side Effect

Answer 21

ONJ

Question 22

Denosumab and bisphosphonates share what common target

Answer 22

Osteoclast inhibition